Transmission disequilibrium test of stromelysin-1 gene variation in relation to Crohn's disease


Pender, S.L.F., Croucher, P.J., Mascheretti, S., Prothero, J.D., Fisher, S.A., MacDonald, T.T., Schreiber, S. and Ye, S. (2004) Transmission disequilibrium test of stromelysin-1 gene variation in relation to Crohn's disease Journal of Medical Genetics, 41, (9), e112. (doi:10.1136/jmg.2004.023572).

Download

Full text not available from this repository.

Description/Abstract

Crohn’s disease (MIM 266600) and ulcerative colitis (MIM 191390) are the major forms of inflammatory bowel disease (MIM 601458), the prevalence of Crohn’s disease being more than 1/1000 in the Western countries.1 Inflammatory bowel disease is characterised by chronic relapsing intestinal inflammation, and its pathogenesis probably involves microbial, immunological, environmental, and genetic factors.2,3 Recent genetic association studies have shown that sequence variations in the Caspase Activating Recruitment Domain (CARD15) gene (MIM605956, formerly named NOD2) on chromosome 16q are a strong genetic factor for Crohn’s disease but not for ulcerative colitis.4–6CARD15 represents the first major Crohn’s disease susceptibility gene identified, and its identification might facilitate the uncovering of other genetic factors for the disease.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1136/jmg.2004.023572
ISSNs: 0022-2593 (print)
Keywords: linkage disequilibrium, peptides, cohort studies, disease, genetic, non-U.S.gov't, stromelysin 1, proteins, Great Britain, human, humans, research support, letter, crohn disease, germany, alleles, polymorphism, genotype, genetics, protein, intracellular signaling peptides and proteins, genetic predisposition to disease, crohn's disease
Subjects:

ePrint ID: 60124
Date :
Date Event
2004Published
Date Deposited: 04 Sep 2008
Last Modified: 16 Apr 2017 17:33
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/60124

Actions (login required)

View Item View Item