X chromosome loss and ageing
X chromosome loss and ageing
The detection of a low level 45,X cell line during routine cytogenetic analysis in an adult female can be difficult to interpret. In the absence of recent information regarding loss of the X chromosome and ageing, we undertook a prospective study. A total of 19,650 cells from 655 females aged from birth to 80 years were screened cytogenetically. The frequency of X chromosome loss ranged from 0.07% at age 65 years of age and showed a highly significant quadratic relationship between X chromosome loss and ageing (P < or = 0.00001). We have produced a graphic representation that provides a minimum baseline age-related rate of X chromosome loss. This should assist diagnostic cytogenetics laboratories to determine the significance of 45,X cell lines detected in women of all ages. We also compared the frequency of 45,X cells in women referred with at least one spontaneous abortion with those referred for other reasons and found no significant difference. Thus, in our population, an excess of 45,X cells is not associated with pregnancy loss.
newborn, infant, chromosomes, child, prospective studies, preschool, aging, x, adult, genetics, cytogenetics, aged, middle aged, human, abortion, age distribution, cell line, humans
181-185
Russell, L.M.
5cf9c799-8ecb-43cf-9f40-625d38680e77
Strike, P.
18228bfb-5099-4840-ab58-155f4b7d1b00
Browne, C.E.
3ba0ce5a-74c7-4564-a274-334c7a39c221
Jacobs, P.A.
32993834-5b30-4706-a09b-640baf848c49
3 October 2007
Russell, L.M.
5cf9c799-8ecb-43cf-9f40-625d38680e77
Strike, P.
18228bfb-5099-4840-ab58-155f4b7d1b00
Browne, C.E.
3ba0ce5a-74c7-4564-a274-334c7a39c221
Jacobs, P.A.
32993834-5b30-4706-a09b-640baf848c49
Russell, L.M., Strike, P., Browne, C.E. and Jacobs, P.A.
(2007)
X chromosome loss and ageing.
Cytogenetic and Genome Research, 116 (3), .
(doi:10.1159/000098184).
Abstract
The detection of a low level 45,X cell line during routine cytogenetic analysis in an adult female can be difficult to interpret. In the absence of recent information regarding loss of the X chromosome and ageing, we undertook a prospective study. A total of 19,650 cells from 655 females aged from birth to 80 years were screened cytogenetically. The frequency of X chromosome loss ranged from 0.07% at age 65 years of age and showed a highly significant quadratic relationship between X chromosome loss and ageing (P < or = 0.00001). We have produced a graphic representation that provides a minimum baseline age-related rate of X chromosome loss. This should assist diagnostic cytogenetics laboratories to determine the significance of 45,X cell lines detected in women of all ages. We also compared the frequency of 45,X cells in women referred with at least one spontaneous abortion with those referred for other reasons and found no significant difference. Thus, in our population, an excess of 45,X cells is not associated with pregnancy loss.
This record has no associated files available for download.
More information
Published date: 3 October 2007
Keywords:
newborn, infant, chromosomes, child, prospective studies, preschool, aging, x, adult, genetics, cytogenetics, aged, middle aged, human, abortion, age distribution, cell line, humans
Organisations:
Human Genetics, Medicine
Identifiers
Local EPrints ID: 60197
URI: http://eprints.soton.ac.uk/id/eprint/60197
ISSN: 1424-8581
PURE UUID: efcc80d3-e9e1-404f-8ede-793e660dbfb8
Catalogue record
Date deposited: 08 Sep 2008
Last modified: 15 Mar 2024 11:19
Export record
Altmetrics
Contributors
Author:
L.M. Russell
Author:
P. Strike
Author:
C.E. Browne
Author:
P.A. Jacobs
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics