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Clinical implications of apoptosis in ischemic myocardium

Record type: Article

Apoptosis, a genetically programmed form of cell death, contributes to myocyte cell loss in a variety of cardiac pathologies, including cardiac failure and those related to ischemia/reperfusion injury. The apoptotic program is complex, involving both pro- and anti-apoptotic proteins, and apoptosis occurs when the equilibrium between these opposing factors is perturbed. Some of these factors are intrinsic to the apoptotic pathway, such as the pro- and anti-apoptotic members of the Bcl2 family. Other, extrinsic, cellular factors can also modify the outcome of the response to an apoptotic stimulus. In this review, we have focused on some of these extrinsic factors, such as STAT-1 as a pro-apoptotic agent and the urocortins and Bag-1 as anti-apoptotic factors, since these may be potential therapeutic targets. In addition, we discuss the profound cytoprotective effects of the antibiotic, minocycline.

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Citation

Scarabelli, Tiziano M., Knight, Richard, Stephanou, Anastasis, Townsend, Paul, Chen-Scarabelli, Carol, Lawrence, Kevin, Gottlieb, Roberta, Latchman, David and Narula, Jagat (2006) Clinical implications of apoptosis in ischemic myocardium Current Problems in Cardiology, 31, (3), pp. 181-264. (doi:10.1016/j.cpcardiol.2005.11.002).

More information

Published date: 2006
Keywords: myocardial reperfusion injury, injuries, urocortins, review, apoptosis regulatory proteins, stat transcription factors, minocycline, protein, animals, myocardial ischemia, autophagy

Identifiers

Local EPrints ID: 60210
URI: http://eprints.soton.ac.uk/id/eprint/60210
ISSN: 0146-2806
PURE UUID: 6e7ab4f9-79c5-4f51-ac88-a2caddff4a3e

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Date deposited: 08 Sep 2008
Last modified: 17 Jul 2017 14:23

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Contributors

Author: Tiziano M. Scarabelli
Author: Richard Knight
Author: Anastasis Stephanou
Author: Paul Townsend
Author: Carol Chen-Scarabelli
Author: Kevin Lawrence
Author: Roberta Gottlieb
Author: David Latchman
Author: Jagat Narula

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