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An assessment of pancreatic endocrine function and insulin sensitivity in patients with transient neonatal diabetes in remission. [In, Fetal and Neonatal edition]

Record type: Article

AIMS: To examine derived indices of beta cell function, peripheral insulin sensitivity, and the pancreatic response to intravenous glucose loading in children with a previous history of transient neonatal diabetes currently in remission, repeated after a period of two or more years.
METHODS: The standard intravenous glucose tolerance test (IVGTT) was used to measure the first phase insulin response (FPIR) cumulatively at one and three minutes. In addition, fasting insulin and glucose values were used to estimate insulinogenic indices (beta cell function) and QUICKI (insulin sensitivity).
PATIENTS: Six patients with known previous transient neonatal diabetes currently in remission with no exogenous insulin requirement were tested. Control data from 15 children of a similar age were available for derived fasting indices of beta cell functional capacity and insulin sensitivity.
RESULTS: One child had a subnormal insulin secretory response to intravenous glucose that remained abnormal two and four years later. The other children had relatively normal or entirely normal responses over two years. Measures of beta cell function and insulin sensitivity in the fasting state showed comparable results to those obtained from normal controls.
CONCLUSIONS: Most children with transient neonatal diabetes in remission have no evidence of beta cell dysfunction or insulin resistance in the fasting state, although they might have been expected to show subtle defects given the tendency to relapse in adolescence. Measures of insulin response to intravenous glucose loading are often normal but suggest future recurrence if profoundly abnormal.

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Citation

Shield, J.P.H., Temple, I.K., Sabin, M., Mackay, D., Robinson, D.O., Betts, P.R., Carson, D.J., Cavé, H., Chevenne, D. and Polak, M. (2004) An assessment of pancreatic endocrine function and insulin sensitivity in patients with transient neonatal diabetes in remission. [In, Fetal and Neonatal edition] Archives of Disease in Childhood - Fetal and Neonatal Edition, 89, (4), F341-F343. (doi:10.1136/adc.2003.030502).

More information

Published date: July 2004
Keywords: diabetes mellitus, remission, pancreatic insufficiency, ß cell function, insulin sensitivity
Organisations: Medicine

Identifiers

Local EPrints ID: 60233
URI: http://eprints.soton.ac.uk/id/eprint/60233
ISSN: 1359-2998
PURE UUID: e3a0723c-b4b2-4e9a-aeaf-e3a48b5b7c9e
ORCID for D. Mackay: ORCID iD orcid.org/0000-0003-3088-4401

Catalogue record

Date deposited: 03 Sep 2008
Last modified: 17 Jul 2017 14:23

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Contributors

Author: J.P.H. Shield
Author: I.K. Temple
Author: M. Sabin
Author: D. Mackay ORCID iD
Author: D.O. Robinson
Author: P.R. Betts
Author: D.J. Carson
Author: H. Cavé
Author: D. Chevenne
Author: M. Polak

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