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STAT1 regulates p73-mediated Bax gene expression

Soond, Surinder M., Carroll, Christopher, Townsend, Paul A., Sayan, Emre, Melino, Gerry, Behrmann, Iris, Knight, Richard A., Latchman, David S. and Stephanou, Anastasis (2007) STAT1 regulates p73-mediated Bax gene expression Febs Letters, 581, (6), pp. 1217-1226. (doi:10.1016/j.febslet.2007.02.049).

Record type: Article

Abstract

Although signal transducer and activator of transcription 1 (STAT1) mediated regulation of p53 transcription and apoptosis has been previously reported, modulation of other members of the p53 family of transcription factors remains poorly understood. In this study, we found that STAT1 and TA-p73 can interact directly and that p73-mediated Bax promoter activity was observed to be reduced by STAT1 expression in a p53-independent manner for which STAT1 Tyrosine-701 and Serine-727 are key residues. This study presents the first report physically linking STAT1 and TA-p73 signalling and highlights the modulation of the Bax promoter in the context of IFN-gamma stimulation.

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Published date: 20 March 2007
Keywords: signal transducer and activator of transcription 1, interferon-gamma, TA-p73, p53, bax

Identifiers

Local EPrints ID: 60253
URI: http://eprints.soton.ac.uk/id/eprint/60253
ISSN: 0014-5793
PURE UUID: b0b0fea3-f34f-42aa-ab3f-58b6ff56c1bb

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Date deposited: 08 Sep 2008
Last modified: 17 Jul 2017 14:23

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Contributors

Author: Surinder M. Soond
Author: Christopher Carroll
Author: Paul A. Townsend
Author: Emre Sayan
Author: Gerry Melino
Author: Iris Behrmann
Author: Richard A. Knight
Author: David S. Latchman
Author: Anastasis Stephanou

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