The University of Southampton
University of Southampton Institutional Repository

Myeloproliferative disorders with translocations of chromosome 5q31-35: role of the platelet-derived growth factor receptor Beta

Myeloproliferative disorders with translocations of chromosome 5q31-35: role of the platelet-derived growth factor receptor Beta
Myeloproliferative disorders with translocations of chromosome 5q31-35: role of the platelet-derived growth factor receptor Beta
Acquired reciprocal chromosomal translocations that involve chromosome bands 5q31-33 are associated with a significant minority of patients with BCR-ABL-negative chronic myeloid leukemias. The most common abnormality is the t(5;12)(q33;p13), which fuses the ETV6/TEL gene to the platelet-derived growth factor receptor-beta (PDGFRB), a receptor tyrosine kinase that maps to 5q33. PDGFRB is disrupted by other translocations and to date four additional partner genes (H4, HIP1, CEV14 and Rab5) have been reported. Clinically, most patients present with a myeloproliferative disorder (MPD) with eosinophilia, eosinophilic leukemia or chronic myelomonocytic leukemia and thus fall into the broader category of myeloproliferative disorders/myelodysplastic syndromes (MPD/MDS). With the advent of targeted signal transduction therapy, patients with rearrangement of PDGFRB might be better classified as a distinct subgroup of MPD/MDS
genetics, myelodysplastic syndromes, chromosomes, myeloproliferative disorders, patients, humans, review, laboratories, eosinophilia, tyrosine, translocation, platelet-derived growth factor, genetic, growth, research support, etiology, non-u.s.gov't, genes, therapy, leukemia, platelet-derived growth factor beta, role, pair 5, signal transduction, receptor, human, syndrome, diagnosis, abnormalities, pair 12
0001-5792
113-122
Steer, E.J.
72d16c6e-56ba-4a02-9f00-8eaf486c96a7
Cross, N.C.
f87650da-b908-4a34-b31b-d62c5f186fe4
Steer, E.J.
72d16c6e-56ba-4a02-9f00-8eaf486c96a7
Cross, N.C.
f87650da-b908-4a34-b31b-d62c5f186fe4

Steer, E.J. and Cross, N.C. (2002) Myeloproliferative disorders with translocations of chromosome 5q31-35: role of the platelet-derived growth factor receptor Beta. Acta Haematologica, 107 (2), 113-122. (doi:10.1159/000068099).

Record type: Article

Abstract

Acquired reciprocal chromosomal translocations that involve chromosome bands 5q31-33 are associated with a significant minority of patients with BCR-ABL-negative chronic myeloid leukemias. The most common abnormality is the t(5;12)(q33;p13), which fuses the ETV6/TEL gene to the platelet-derived growth factor receptor-beta (PDGFRB), a receptor tyrosine kinase that maps to 5q33. PDGFRB is disrupted by other translocations and to date four additional partner genes (H4, HIP1, CEV14 and Rab5) have been reported. Clinically, most patients present with a myeloproliferative disorder (MPD) with eosinophilia, eosinophilic leukemia or chronic myelomonocytic leukemia and thus fall into the broader category of myeloproliferative disorders/myelodysplastic syndromes (MPD/MDS). With the advent of targeted signal transduction therapy, patients with rearrangement of PDGFRB might be better classified as a distinct subgroup of MPD/MDS

This record has no associated files available for download.

More information

Published date: 2002
Keywords: genetics, myelodysplastic syndromes, chromosomes, myeloproliferative disorders, patients, humans, review, laboratories, eosinophilia, tyrosine, translocation, platelet-derived growth factor, genetic, growth, research support, etiology, non-u.s.gov't, genes, therapy, leukemia, platelet-derived growth factor beta, role, pair 5, signal transduction, receptor, human, syndrome, diagnosis, abnormalities, pair 12

Identifiers

Local EPrints ID: 60260
URI: http://eprints.soton.ac.uk/id/eprint/60260
ISSN: 0001-5792
PURE UUID: 4bf7e942-daa4-4332-a8b3-512538a35977
ORCID for N.C. Cross: ORCID iD orcid.org/0000-0001-5481-2555

Catalogue record

Date deposited: 02 Sep 2008
Last modified: 16 Mar 2024 03:23

Export record

Altmetrics

Contributors

Author: E.J. Steer
Author: N.C. Cross ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×