Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10
Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10
Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted. No myelin was generated upon transplantation of Sox10-deficient neural stem cells into wild-type hosts showing the permanent, cell-autonomous nature of the defect. Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms.
sox, glial cells, HMG, PLP, MBP, neuregulin
165-170
Stolt, C. Claus
b52098b4-2204-429a-a516-740a257f9289
Rehberg, Stephan
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Ader, Marius
c9f648df-e397-4af1-a5f9-6893e2811a92
Lommes, Petra
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Riethmacher, Dieter
1a0a0c2e-e94d-4d0a-a890-90107a2545bc
Schachner, Melitta
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Bartsch, Udo
a0292695-52cc-493c-9dd4-f8fdb0f4097f
Wegner, Michael
8f1ecdbd-7edc-435f-85d2-f9f860402e3f
15 January 2002
Stolt, C. Claus
b52098b4-2204-429a-a516-740a257f9289
Rehberg, Stephan
7e71a1e2-6a9e-4bb1-b52f-3a8cae4dac2d
Ader, Marius
c9f648df-e397-4af1-a5f9-6893e2811a92
Lommes, Petra
85039c48-0d2c-4988-b8d6-272839ba453f
Riethmacher, Dieter
1a0a0c2e-e94d-4d0a-a890-90107a2545bc
Schachner, Melitta
e699917d-fb4d-4435-a71b-f90e3e84874d
Bartsch, Udo
a0292695-52cc-493c-9dd4-f8fdb0f4097f
Wegner, Michael
8f1ecdbd-7edc-435f-85d2-f9f860402e3f
Stolt, C. Claus, Rehberg, Stephan, Ader, Marius, Lommes, Petra, Riethmacher, Dieter, Schachner, Melitta, Bartsch, Udo and Wegner, Michael
(2002)
Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10.
Genes & Development, 16 (2), .
(doi:10.1101/gad.215802).
Abstract
Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted. No myelin was generated upon transplantation of Sox10-deficient neural stem cells into wild-type hosts showing the permanent, cell-autonomous nature of the defect. Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms.
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Published date: 15 January 2002
Keywords:
sox, glial cells, HMG, PLP, MBP, neuregulin
Identifiers
Local EPrints ID: 60264
URI: http://eprints.soton.ac.uk/id/eprint/60264
ISSN: 0890-9369
PURE UUID: 38377534-efa7-44b7-b00c-1bfc4abc53f1
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Date deposited: 08 Sep 2008
Last modified: 16 Mar 2024 03:56
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Author:
C. Claus Stolt
Author:
Stephan Rehberg
Author:
Marius Ader
Author:
Petra Lommes
Author:
Dieter Riethmacher
Author:
Melitta Schachner
Author:
Udo Bartsch
Author:
Michael Wegner
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