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Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10

Record type: Article

Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted. No myelin was generated upon transplantation of Sox10-deficient neural stem cells into wild-type hosts showing the permanent, cell-autonomous nature of the defect. Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms.

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Citation

Stolt, C. Claus, Rehberg, Stephan, Ader, Marius, Lommes, Petra, Riethmacher, Dieter, Schachner, Melitta, Bartsch, Udo and Wegner, Michael (2002) Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10 Genes & Development, 16, (2), pp. 165-170. (doi:10.1101/gad.215802).

More information

Published date: 15 January 2002
Keywords: sox, glial cells, HMG, PLP, MBP, neuregulin

Identifiers

Local EPrints ID: 60264
URI: http://eprints.soton.ac.uk/id/eprint/60264
ISSN: 0890-9369
PURE UUID: 38377534-efa7-44b7-b00c-1bfc4abc53f1

Catalogue record

Date deposited: 08 Sep 2008
Last modified: 17 Jul 2017 14:23

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