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Linkage disequilibrium maps and location databases

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Effective application of association mapping for complex traits requires characterization of linkage disequilibrium (LD) patterns that reflect the dominant process of recombination and its duration in addition to the more subtle influences of mutation, selection, and genetic drift. Maps expressed in linkage disequilibrium units (LDUs) reflect the influences of these factors with the use of a modified version of Malecot’s isolation-by-distance model. As a result, LDU maps are analogous to linkage maps in so far as their provision of an additive metric that is related to recombination and facilitates association-mapping studies. However, unlike linkage maps, LDUs also reflect the partly cumulative effects of multiple historical bottlenecks that account for substantial variations in LD patterns between populations. This chapter provides an overview of the data requirements and methodology used to construct LDU maps, their applications outside association mapping, and their integration into location databases.

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Citation

Tapper, William (2008) Linkage disequilibrium maps and location databases In, Collins, Andrew R. (eds.) Linkage Disequilibrium and Association Mapping: Analysis and Applications. Totowa, USA, Humana pp. 23-45. (Methods in Molecular Biology, 376). (doi:10.1007/978-1-59745-389-9_3).

More information

Published date: 5 February 2008
Additional Information: ISSN 1064-3745
Keywords: linkage disequilibrium unit, malecot model, recombination, hot spot, snp selectiongene mapping, methods, genomics, statistical methods

Identifiers

Local EPrints ID: 60285
URI: http://eprints.soton.ac.uk/id/eprint/60285
ISBN: 9781588296696
PURE UUID: 25b27282-93ec-4193-8110-81ba9ca8a110

Catalogue record

Date deposited: 28 Oct 2008
Last modified: 17 Jul 2017 14:23

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Contributors

Author: William Tapper
Editor: Andrew R. Collins

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