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Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury

Valentim, Lauren, Laurence, Kevin M., Townsend, Paul A., Carroll, Christopher J., Soond, Surinder, Scarabelli, Tiziano M., Knight, Richard A., Latchman, David S. and Stephanou, Anastasis (2006) Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury Journal of Molecular and Cellular Cardiology, 40, (6), pp. 846-852. (doi:10.1016/j.yjmcc.2006.03.428).

Record type: Article


Autophagy is known to be a feature of cardiomyopathies and chronic ischaemia. Here we demonstrate that autophagy is also induced by a single cycle of ischaemia/reperfusion (I/R in neonatal and adult rat cardiac myocytes). Consistent with the critical role for Beclin1 in autophagocytosis, reduction of Beclin1 expression in cardiac myocytes by RNAi reduces I/R-induced autophagy and this is associated with enhanced cell survival. Autophagy is also reduced by urocortin, an endogenous cardiac peptide which we have previously shown to reduce other forms of myocyte cell death induced by I/R. The inhibition of autophagy by urocortin is mediated in part by inhibition of Beclin1 expression, an effect which is mediated by activation of the PI3 kinase/Akt pathway but which does not involve activation of p42/p44 MAPK.

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Published date: June 2006
Keywords: cardiac, research, myocytes, injuries, apoptosis, rats, adult, animals, cytology, inhibition, london, proteins, cardiomyopathies, survival, autophagy, autophagocytosis


Local EPrints ID: 60351
PURE UUID: 61c25282-a077-4c52-82af-8f77616a71d5

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Date deposited: 08 Sep 2008
Last modified: 17 Jul 2017 14:23

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Author: Lauren Valentim
Author: Kevin M. Laurence
Author: Paul A. Townsend
Author: Christopher J. Carroll
Author: Surinder Soond
Author: Tiziano M. Scarabelli
Author: Richard A. Knight
Author: David S. Latchman
Author: Anastasis Stephanou

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