Chronicles of a switch hunt: gcm genes in development
Chronicles of a switch hunt: gcm genes in development
Co-conservation of sequence and function is an important principle during evolution. As a consequence, sequence-related genes often have similar functions in evolutionarily distant species. Enter the 'glial cells missing' (gcm) genes. They code for a small family of novel transcription factors that share DNA-binding properties and domain structure. However, no evolutionarily conserved function is apparent as yet. The prototypical gcm from Drosophila dominates nervous system development as a fate switch and master regulator of gliogenesis, whereas mammalian gcm genes have roles in placental morphogenesis and development of the parathyroid gland. Apparently, structure and function sometimes can go separate ways.
glia, neuron, placenta, trophoblast, parathyroid, transcripton, stem cell, cell fate, conservation
286-290
Wegner, Michael
8f1ecdbd-7edc-435f-85d2-f9f860402e3f
Riethmacher, Dieter
1a0a0c2e-e94d-4d0a-a890-90107a2545bc
1 May 2001
Wegner, Michael
8f1ecdbd-7edc-435f-85d2-f9f860402e3f
Riethmacher, Dieter
1a0a0c2e-e94d-4d0a-a890-90107a2545bc
Wegner, Michael and Riethmacher, Dieter
(2001)
Chronicles of a switch hunt: gcm genes in development.
Trends in Genetics, 17 (5), .
(doi:10.1016/S0168-9525(01)02275-2).
Abstract
Co-conservation of sequence and function is an important principle during evolution. As a consequence, sequence-related genes often have similar functions in evolutionarily distant species. Enter the 'glial cells missing' (gcm) genes. They code for a small family of novel transcription factors that share DNA-binding properties and domain structure. However, no evolutionarily conserved function is apparent as yet. The prototypical gcm from Drosophila dominates nervous system development as a fate switch and master regulator of gliogenesis, whereas mammalian gcm genes have roles in placental morphogenesis and development of the parathyroid gland. Apparently, structure and function sometimes can go separate ways.
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Published date: 1 May 2001
Keywords:
glia, neuron, placenta, trophoblast, parathyroid, transcripton, stem cell, cell fate, conservation
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Local EPrints ID: 60406
URI: http://eprints.soton.ac.uk/id/eprint/60406
ISSN: 0168-9525
PURE UUID: 887e933e-c6ce-439c-8e5c-22e04b46da00
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Date deposited: 08 Sep 2008
Last modified: 16 Mar 2024 03:56
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Author:
Michael Wegner
Author:
Dieter Riethmacher
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