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A 2-year-old with atypical CML with a t(5;12)(q33;p13) treated successfully with imatinib mesylate

Wittman, Brenda, Horan, John, Baxter, Joanna, Goldberg, John, Felgar, Raymond, Baylor, Erin, Cromwell, Bean, Cross, Nicholas and Bennett, John M. (2004) A 2-year-old with atypical CML with a t(5;12)(q33;p13) treated successfully with imatinib mesylate Leukemia Research, 28, (Supplement 1), pp. 65-69. (doi:10.1016/j.leukres.2003.10.011).

Record type: Article

Abstract

Atypical chronic myelogenous leukemia (aCML) is a myelodysplastic/myeloproliferative disorder that usually occurs in older adults. Here we report a pediatric patient with aCML and a t(5;12)(q33;p13) with a corresponding fusion gene ETV6-PDGFRB. Because the PDGFRB tyrosine kinase is one of the known targets of tyrosine kinase inhibitors, this patient achieved cytogenetic and molecular remission with treatment with imatinib mesylate (formerly STI571; now Gleevec in the United States and Glivec in Europe). This case illustrates one of many myelodysplastic/myeloproliferative disorders that can be treated with this particular tyrosine kinase inhibitor.

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Published date: May 2004

Identifiers

Local EPrints ID: 60436
URI: http://eprints.soton.ac.uk/id/eprint/60436
ISSN: 0145-2126
PURE UUID: 86dea32f-5610-4671-9c3b-aa8ec69fccd5
ORCID for Nicholas Cross: ORCID iD orcid.org/0000-0001-5481-2555

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Date deposited: 19 Nov 2008
Last modified: 17 Jul 2017 14:23

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Contributors

Author: Brenda Wittman
Author: John Horan
Author: Joanna Baxter
Author: John Goldberg
Author: Raymond Felgar
Author: Erin Baylor
Author: Bean Cromwell
Author: Nicholas Cross ORCID iD
Author: John M. Bennett

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