The University of Southampton
University of Southampton Institutional Repository

A 2-year-old with atypical CML with a t(5;12)(q33;p13) treated successfully with imatinib mesylate

Wittman, Brenda, Horan, John, Baxter, Joanna, Goldberg, John, Felgar, Raymond, Baylor, Erin, Cromwell, Bean, Cross, Nicholas and Bennett, John M. (2004) A 2-year-old with atypical CML with a t(5;12)(q33;p13) treated successfully with imatinib mesylate Leukemia Research, 28, (Supplement 1), pp. 65-69. (doi:10.1016/j.leukres.2003.10.011).

Record type: Article


Atypical chronic myelogenous leukemia (aCML) is a myelodysplastic/myeloproliferative disorder that usually occurs in older adults. Here we report a pediatric patient with aCML and a t(5;12)(q33;p13) with a corresponding fusion gene ETV6-PDGFRB. Because the PDGFRB tyrosine kinase is one of the known targets of tyrosine kinase inhibitors, this patient achieved cytogenetic and molecular remission with treatment with imatinib mesylate (formerly STI571; now Gleevec in the United States and Glivec in Europe). This case illustrates one of many myelodysplastic/myeloproliferative disorders that can be treated with this particular tyrosine kinase inhibitor.

Full text not available from this repository.

More information

Published date: May 2004


Local EPrints ID: 60436
ISSN: 0145-2126
PURE UUID: 86dea32f-5610-4671-9c3b-aa8ec69fccd5
ORCID for Nicholas Cross: ORCID iD

Catalogue record

Date deposited: 19 Nov 2008
Last modified: 17 Jul 2017 14:23

Export record



Author: Brenda Wittman
Author: John Horan
Author: Joanna Baxter
Author: John Goldberg
Author: Raymond Felgar
Author: Erin Baylor
Author: Bean Cromwell
Author: Nicholas Cross ORCID iD
Author: John M. Bennett

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.