Antenatal carbimazole and choanal atresia: a new embryopathy
Antenatal carbimazole and choanal atresia: a new embryopathy
Carbimazole embryopathy is a recently recognized and defined phenotype. Choanal atresia; gastrointestinal anomalies, particularly esophageal atresia; athelia or hypothelia; developmental delay; hearing loss; aplasia cutis; and dysmorphic facial features all can occur after exposure to the antithyroid drugs carbimazole or methimazole during gestation. Although full expression of this phenotype appears to be an uncommon sequelae of antenatal carbimazole exposure, infants with less overt manifestations may remain with the condition undiagnosed. It is clearly important when an infant with choanal atresia is assessed to take an adequate drug history and consider this embryopathy as a potential causative factor
infant, abnormalities, expression, choanal atresia, humans, multiple, adverse effects, exposure, agents, pregnancy complications, london, pregnancy, carbimazole, drug therapy, graves disease, newborn, report, hearing loss, england, phenotype, genetics, therapeutic use, female, antithyroid agents, chemically induced, history
1009-1011
Wolf, D.
07185115-3849-4f7d-a90c-ae78271a86c0
Foulds, N.
5e153e9f-caae-45f5-b6f0-943bd567558e
Daya, H.
2ac3f9ef-4749-4947-a15d-5ec398e44e79
2006
Wolf, D.
07185115-3849-4f7d-a90c-ae78271a86c0
Foulds, N.
5e153e9f-caae-45f5-b6f0-943bd567558e
Daya, H.
2ac3f9ef-4749-4947-a15d-5ec398e44e79
Wolf, D., Foulds, N. and Daya, H.
(2006)
Antenatal carbimazole and choanal atresia: a new embryopathy.
Archives of Otolaryngology - Head & Neck Surgery, 132 (9), .
Abstract
Carbimazole embryopathy is a recently recognized and defined phenotype. Choanal atresia; gastrointestinal anomalies, particularly esophageal atresia; athelia or hypothelia; developmental delay; hearing loss; aplasia cutis; and dysmorphic facial features all can occur after exposure to the antithyroid drugs carbimazole or methimazole during gestation. Although full expression of this phenotype appears to be an uncommon sequelae of antenatal carbimazole exposure, infants with less overt manifestations may remain with the condition undiagnosed. It is clearly important when an infant with choanal atresia is assessed to take an adequate drug history and consider this embryopathy as a potential causative factor
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Published date: 2006
Keywords:
infant, abnormalities, expression, choanal atresia, humans, multiple, adverse effects, exposure, agents, pregnancy complications, london, pregnancy, carbimazole, drug therapy, graves disease, newborn, report, hearing loss, england, phenotype, genetics, therapeutic use, female, antithyroid agents, chemically induced, history
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Local EPrints ID: 60438
URI: http://eprints.soton.ac.uk/id/eprint/60438
ISSN: 0886-4470
PURE UUID: de2b6444-1dce-4db2-ab2a-44b8ca2678c3
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Date deposited: 04 Sep 2008
Last modified: 08 Jan 2022 16:03
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Author:
D. Wolf
Author:
N. Foulds
Author:
H. Daya
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