Modulation of Sterol Regulatory Element-Binding Proteins (SREBPs) as potential treatments for Non-alcoholic Fatty Liver Disease (NAFLD)
Modulation of Sterol Regulatory Element-Binding Proteins (SREBPs) as potential treatments for Non-alcoholic Fatty Liver Disease (NAFLD)
Non-alcoholic fatty liver disease (NAFLD) is associated with diabetes, obesity and insulin resistance. The pathogenesis of NAFLD is complex, but modulation of the activities of transcription factors that regulate hepatic lipid and glucose homeostasis may be a key to treating NAFLD. An example of a key transcription factor regulating hepatic lipid metabolism is sterol regulatory element binding proteins (SREBPs), and in this review we present evidence supporting a key role for SREBPs in NAFLD. Currently, the only effective treatment for NAFLD is caloric restriction and peroxisome proliferator activated receptor (PPAR-?) agonists. We suggest that further studies are urgently needed to evaluate modulation of SREBP activity as a potential new treatment for NAFLD.
liver, protein, proteins, fatty liver, disease
740-747
Ahmed, Mohamed H.
ed037a05-9770-4c1f-80a8-bd79fc83ee35
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
September 2007
Ahmed, Mohamed H.
ed037a05-9770-4c1f-80a8-bd79fc83ee35
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Ahmed, Mohamed H. and Byrne, Christopher D.
(2007)
Modulation of Sterol Regulatory Element-Binding Proteins (SREBPs) as potential treatments for Non-alcoholic Fatty Liver Disease (NAFLD).
Drug Discovery Today, 12 (17/18), .
(doi:10.1016/j.drudis.2007.07.009).
Abstract
Non-alcoholic fatty liver disease (NAFLD) is associated with diabetes, obesity and insulin resistance. The pathogenesis of NAFLD is complex, but modulation of the activities of transcription factors that regulate hepatic lipid and glucose homeostasis may be a key to treating NAFLD. An example of a key transcription factor regulating hepatic lipid metabolism is sterol regulatory element binding proteins (SREBPs), and in this review we present evidence supporting a key role for SREBPs in NAFLD. Currently, the only effective treatment for NAFLD is caloric restriction and peroxisome proliferator activated receptor (PPAR-?) agonists. We suggest that further studies are urgently needed to evaluate modulation of SREBP activity as a potential new treatment for NAFLD.
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Published date: September 2007
Keywords:
liver, protein, proteins, fatty liver, disease
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Local EPrints ID: 60861
URI: http://eprints.soton.ac.uk/id/eprint/60861
ISSN: 1359-6446
PURE UUID: ab77b11f-0580-4f9d-ac50-4a2ab4a7cc43
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Date deposited: 10 Sep 2008
Last modified: 16 Mar 2024 03:07
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Author:
Mohamed H. Ahmed
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