Drug treatment and type 2 diabetes: the impact of liver disease
Drug treatment and type 2 diabetes: the impact of liver disease
Although most liver diseases can occur coincidentally and sporadically with diabetes, non-alcoholic fatty liver disease (NAFLD) is frequently associated with insulin resistance and overweight, and occurs commonly with type 2 diabetes. Interestingly, NAFLD is not only regarded as a hepatic component of the metabolic syndrome, but also as an independent risk factor and a marker for increase in cardiovascular disease (CVD). Significantly, NAFLD is associated with an increased risk of all-cause death and predicts future CVD events independently of age, sex, LDL-cholesterol, smoking and the cluster of features of the metabolic syndrome. Although there was initial concern about drug toxicity with NAFLD, increasing evidence is suggesting that commonly used drugs such as metformin, statins and antihypertensives are probably safe and the glitazone group of drugs may even confer a therapeutic benefit and improve features of NAFLD. Certain sulphonylurea drugs and acarbose may cause an increase in liver enzymes but rarely do these drugs cause overt liver disease. In this review we have focused on the safety and therapeutic impact of thiazolidinediones (TZDs), statins and renin-angiotensin inhibitors in NAFLD as this is by far the most common liver disease in type 2 diabetes. We also discuss drug-induced liver toxicity and drug safety in liver disease relevant to diabetes treatment. Copyright © 2007 John Wiley & Sons.
type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), insulin resistance, statins and angiotensin-converting enzyme inhibitors, thiazolidinediones (TZDs)
318-323
Ahmed, M.H.
0dcfcd8b-55bc-48dc-9dbe-24df7fe58269
Byrne, C.D.
1370b997-cead-4229-83a7-53301ed2a43c
July 2007
Ahmed, M.H.
0dcfcd8b-55bc-48dc-9dbe-24df7fe58269
Byrne, C.D.
1370b997-cead-4229-83a7-53301ed2a43c
Ahmed, M.H. and Byrne, C.D.
(2007)
Drug treatment and type 2 diabetes: the impact of liver disease.
Practical Diabetes International, 24 (6), .
(doi:10.1002/pdi.1132).
Abstract
Although most liver diseases can occur coincidentally and sporadically with diabetes, non-alcoholic fatty liver disease (NAFLD) is frequently associated with insulin resistance and overweight, and occurs commonly with type 2 diabetes. Interestingly, NAFLD is not only regarded as a hepatic component of the metabolic syndrome, but also as an independent risk factor and a marker for increase in cardiovascular disease (CVD). Significantly, NAFLD is associated with an increased risk of all-cause death and predicts future CVD events independently of age, sex, LDL-cholesterol, smoking and the cluster of features of the metabolic syndrome. Although there was initial concern about drug toxicity with NAFLD, increasing evidence is suggesting that commonly used drugs such as metformin, statins and antihypertensives are probably safe and the glitazone group of drugs may even confer a therapeutic benefit and improve features of NAFLD. Certain sulphonylurea drugs and acarbose may cause an increase in liver enzymes but rarely do these drugs cause overt liver disease. In this review we have focused on the safety and therapeutic impact of thiazolidinediones (TZDs), statins and renin-angiotensin inhibitors in NAFLD as this is by far the most common liver disease in type 2 diabetes. We also discuss drug-induced liver toxicity and drug safety in liver disease relevant to diabetes treatment. Copyright © 2007 John Wiley & Sons.
This record has no associated files available for download.
More information
Published date: July 2007
Keywords:
type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), insulin resistance, statins and angiotensin-converting enzyme inhibitors, thiazolidinediones (TZDs)
Identifiers
Local EPrints ID: 60862
URI: http://eprints.soton.ac.uk/id/eprint/60862
PURE UUID: d5665a0e-8124-4941-851b-c3567f9b92f8
Catalogue record
Date deposited: 10 Sep 2008
Last modified: 16 Mar 2024 03:07
Export record
Altmetrics
Contributors
Author:
M.H. Ahmed
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics