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Osteoarthritis: pathobiology - targets and ways for therapeutic intervention. [In: Drug Delivery in Degenerative Joint Disease]

Aigner, T., Sachse, A., Gebhard, P.M. and Roach, H.I. (2006) Osteoarthritis: pathobiology - targets and ways for therapeutic intervention. [In: Drug Delivery in Degenerative Joint Disease] Advanced Drug Delivery Reviews, 58, (2), pp. 128-149. (doi:10.1016/j.addr.2006.01.020).

Record type: Article

Abstract

Osteoarthritis is first and foremost the ongoing destruction of the articular cartilages of joints. Therefore, the extracellular matrix and the cells of the articular cartilages are the primary targets of osteoarthritis therapy. This tries to inhibit enzymatic destruction of the extracellular cartilage matrix as well as the modification of the cellular phenotype of the chondrocytes: cell degeneration and cell death are alongside anabolic activation and stabilization of the cellular phenotype of major interest. However, apart from the cartilage and its cells, other tissues of the joints are also important for the symptoms of the disease, which basically all originate outside the articular cartilage. In addition, changes in the subchondral bone as well as the synovial capsule and membrane are important at least for the progression of the disease process. All the named tissues offer different directions and ways for therapeutic intervention.

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Published date: 20 May 2006
Keywords: therapeutic use, cells, therapy, drug delivery systems, chondrocytes, drug therapy, disease, pathology, humans, administration & dosage, review, antirheumatic agents, trends, membrane, osteoarthritis, phenotype, joint diseases, germany, extracellular matrix, bone, cartilage, drugs, joints, senescence, cartilage regeneration

Identifiers

Local EPrints ID: 60864
URI: http://eprints.soton.ac.uk/id/eprint/60864
ISSN: 0169-409X
PURE UUID: 80ab8167-508e-474f-bb7d-4421174c345e

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Date deposited: 02 Sep 2008
Last modified: 17 Jul 2017 14:23

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Contributors

Author: T. Aigner
Author: A. Sachse
Author: P.M. Gebhard
Author: H.I. Roach

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