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A randomised controlled trial of tidal irrigation vs corticosteroid injection in knee osteoarthritis: the KIVIS Study

Arden, N.K., Reading, I.C., Jordan, K.M., Thomas, L., Platten, H., Hassan, A. and Ledingham, J. (2008) A randomised controlled trial of tidal irrigation vs corticosteroid injection in knee osteoarthritis: the KIVIS Study Osteoarthritis and Cartilage, 16, (6), pp. 733-739. (doi:10.1016/j.joca.2007.10.011).

Record type: Article

Abstract

OBJECTIVES: Patients with knee osteoarthritis (OA) often suffer pain that is not fully controlled by analgesics and often require intra-articular therapies. The aim of this study was to compare the benefits of intra-articular corticosteroid injections (CSIs) and tidal irrigation (TI) in patients with OA of the knee.

METHODS: We performed a dual-centre, single blind, randomised, parallel group trial comparing TI and CSI. Patients with knee OA were randomised to either irrigation using a 3.2mm arthroscope under local anaesthesia or an intra-articular injection of 40mg triamcinolone acetonide and 1% lidocaine. Patients were followed for 6 months. The primary outcome measure was the Western Ontario and McMaster Universities OA Index total pain score (visual analogue scale, VAS).

RESULTS: One hundred and fifty patients were recruited of whom 71 received TI and 79 CSI. In both treatment groups, over 80% of patients reported improvement at 2 and 4 weeks. After this time, the benefit of CSI decreased whereas that of TI was maintained: at 26 weeks the pain relief afforded by TI was significantly greater than that of CSI. At 26 weeks 29% of the CSI group reported improvement vs 64% of the TI group (P<0.001). Patients with a knee effusion responded better to both treatments, however, this was most apparent for CSI. Patients with less severe radiographic OA also obtained the greatest improvement from both treatments.

CONCLUSION: Both procedures lead to significant short-term pain relief of at least 4 weeks, however, TI displayed a significantly greater duration of benefit. Patients with effusions and milder radiographic change obtained the best response to treatment.

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More information

Published date: 2008
Keywords: time, bone, injections, osteoarthritis, pain, therapy, methods

Identifiers

Local EPrints ID: 60873
URI: http://eprints.soton.ac.uk/id/eprint/60873
ISSN: 1063-4584
PURE UUID: 3a2e5d1f-c843-4a12-ad9c-8f8c3f774d01

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Date deposited: 09 Sep 2008
Last modified: 17 Jul 2017 14:23

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Contributors

Author: N.K. Arden
Author: I.C. Reading
Author: K.M. Jordan
Author: L. Thomas
Author: H. Platten
Author: A. Hassan
Author: J. Ledingham

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