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Relationship between birth weight and urea kinetics in children

Relationship between birth weight and urea kinetics in children
Relationship between birth weight and urea kinetics in children
OBJECTIVE: To explore the effect of birth weight on urea kinetics in young healthy children. DESIGN: Observational study. SETTING: Tertiary center for treatment of malnutrition. SUBJECTS: A total of 17 male children, 6-24 months old, who had recovered from malnutrition. INTERVENTIONS: Urea kinetics were measured using stable isotope methodology with [(15)N(15)N]-urea over 36 h. RESULTS: Birth weight was negatively related to urea hydrolysis after controlling for the intake of protein (adjusted R (2 ) = 0.91, P = 0.001) and separately for energy intake (adjusted R (2) = 0.95, P = 0.001), age (adjusted R (2) = 0.90, P = 0.001) and rate of weight gain (adjusted R (2) = 0.91, P = 0.001). There was a tendency for higher urea production in the children with lower birth weight after controlling for nitrogen intake (adjusted R (2) = 0.93, P = 0.099), and separately for age (adjusted R (2) = 0.94, P = 0.06) and rate of weight gain (adjusted (R (2) = 0.92, P = 0.096). Urea excretion was not significantly related to birth weight. CONCLUSIONS: The salvaging of urea nitrogen following urea hydrolysis contributed significantly more to the nitrogen economy in children with lower birth weight compared to those with higher birth weight. This may be as a result of reductive adaptation in the children with lower birth weight as a consequence of inappropriate prenatal nutrition and growth
physiology, jamaica, diagnostic use, urea, diet therapy, urine, malnutrition, administration & dosage, nitrogen, proteins, dietary proteins, energy intake, age factors, male, prenatal nutrition, physiological, pharmacokinetics, weight gain, kinetics, infant, nitrogen isotopes, child, birth, humans, birth-weight, protein, research, preschool, nutrition, metabolism, birth weight, adaptation, growth, infant nutrition disorders, weight
0954-3007
197-202
Badaloo, A.V.
b5c857b9-68f4-459e-a27d-33ca45097fd6
Reid, M.
c7588a19-e6a2-4c6a-acc2-0f562c1798fd
Boyne, M.
a22b2b0b-fa0c-4b81-9325-423e5a20e6d0
Jackson, A.A.
c9a12d7c-b4d6-4c92-820e-890a688379ef
Forrester, T.
84984e0d-1dd5-479c-91ed-b3d9c0fbd9d3
Badaloo, A.V.
b5c857b9-68f4-459e-a27d-33ca45097fd6
Reid, M.
c7588a19-e6a2-4c6a-acc2-0f562c1798fd
Boyne, M.
a22b2b0b-fa0c-4b81-9325-423e5a20e6d0
Jackson, A.A.
c9a12d7c-b4d6-4c92-820e-890a688379ef
Forrester, T.
84984e0d-1dd5-479c-91ed-b3d9c0fbd9d3

Badaloo, A.V., Reid, M., Boyne, M., Jackson, A.A. and Forrester, T. (2006) Relationship between birth weight and urea kinetics in children. European Journal of Clinical Nutrition, 60 (2), 197-202.

Record type: Article

Abstract

OBJECTIVE: To explore the effect of birth weight on urea kinetics in young healthy children. DESIGN: Observational study. SETTING: Tertiary center for treatment of malnutrition. SUBJECTS: A total of 17 male children, 6-24 months old, who had recovered from malnutrition. INTERVENTIONS: Urea kinetics were measured using stable isotope methodology with [(15)N(15)N]-urea over 36 h. RESULTS: Birth weight was negatively related to urea hydrolysis after controlling for the intake of protein (adjusted R (2 ) = 0.91, P = 0.001) and separately for energy intake (adjusted R (2) = 0.95, P = 0.001), age (adjusted R (2) = 0.90, P = 0.001) and rate of weight gain (adjusted R (2) = 0.91, P = 0.001). There was a tendency for higher urea production in the children with lower birth weight after controlling for nitrogen intake (adjusted R (2) = 0.93, P = 0.099), and separately for age (adjusted R (2) = 0.94, P = 0.06) and rate of weight gain (adjusted (R (2) = 0.92, P = 0.096). Urea excretion was not significantly related to birth weight. CONCLUSIONS: The salvaging of urea nitrogen following urea hydrolysis contributed significantly more to the nitrogen economy in children with lower birth weight compared to those with higher birth weight. This may be as a result of reductive adaptation in the children with lower birth weight as a consequence of inappropriate prenatal nutrition and growth

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More information

Published date: 2006
Keywords: physiology, jamaica, diagnostic use, urea, diet therapy, urine, malnutrition, administration & dosage, nitrogen, proteins, dietary proteins, energy intake, age factors, male, prenatal nutrition, physiological, pharmacokinetics, weight gain, kinetics, infant, nitrogen isotopes, child, birth, humans, birth-weight, protein, research, preschool, nutrition, metabolism, birth weight, adaptation, growth, infant nutrition disorders, weight

Identifiers

Local EPrints ID: 60882
URI: http://eprints.soton.ac.uk/id/eprint/60882
ISSN: 0954-3007
PURE UUID: 67283ccb-0fa5-4ff6-b830-ee6c33ddaa47

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Date deposited: 11 Sep 2008
Last modified: 13 Mar 2019 20:29

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Contributors

Author: A.V. Badaloo
Author: M. Reid
Author: M. Boyne
Author: A.A. Jackson
Author: T. Forrester

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