The University of Southampton
University of Southampton Institutional Repository

Mechanisms of disease: in utero programming in the pathogenesis of hypertension

Barker, David J.P., Bagby, Susan P. and Hanson, Mark A. (2006) Mechanisms of disease: in utero programming in the pathogenesis of hypertension Nature Clinical Practice Nephrology, 2, (12), pp. 700-707. (doi:10.1038/ncpneph0344).

Record type: Article

Abstract

Nutritional and other environmental cues during development can permanently alter the structure, homeostatic systems, and functions of the body. This phenomenon has been referred to as 'programming'. Epidemiological and animal studies show that programmed effects operate within the normal range of growth and development, and influence the risk of chronic disease in adult life. We review the evidence that these effects include reduced nephron number and compensatory adaptations, which might lead to hypertension, and perhaps accelerate the decline in renal function that accompanies aging. These processes might be exacerbated by programmed changes in vascular structure and function, and alterations in endocrine and metabolic homeostasis. Programmed effects might be initiated as early as the periconceptual phase of development, and could involve epigenetic changes in gene expression or altered stem cell allocation. Better understanding of these processes could lead to the development of novel diagnostic and preventive measures, and to early detection of at-risk individuals. By monitoring blood pressure, weight, and renal function in children, it might be possible to reduce the risk of cardiovascular and renal disease in later life.

Full text not available from this repository.

More information

Published date: December 2006

Identifiers

Local EPrints ID: 60885
URI: http://eprints.soton.ac.uk/id/eprint/60885
ISSN: 1745-8323
PURE UUID: f4449bfe-1e59-497d-9a14-5c128261d2e3

Catalogue record

Date deposited: 22 Sep 2008
Last modified: 17 Jul 2017 14:23

Export record

Altmetrics

Contributors

Author: David J.P. Barker
Author: Susan P. Bagby
Author: Mark A. Hanson

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×