The origins of the developmental origins theory
The origins of the developmental origins theory
Current orthodoxy states that coronary heart disease results from the unhealthy lifestyles of westernized adults together with a contribution from genetic inheritance. This does not provide a secure basis for prevention of the disease. Geographical studies gave the first clue that the disease originates during intra-uterine development. Variations in mortality from the disease across England and Wales were shown to correlate closely with past differences in death rates among newborn babies. In the past most deaths among newborns were attributed to low birthweight. This led to the hypothesis that undernutrition in utero permanently changes the body's structure, function and metabolism in ways that lead to coronary heart disease in later life. The association between low birthweight and coronary heart disease has been confirmed in longitudinal studies of men and women around the world. The developmental model of the origins of the disease offers a new way forward
epidemiology, life style, pregnancy, male, wales, infant, origins, metabolism, coronary disease, disease, heart, physiopathology, england and wales, physiology, in-utero, fetal development, newborn, england, etiology, mortality, hypothesis, function, female, social conditions, review, fetal nutrition disorders, undernutrition, women, longitudinal studies, adult, coronary heart disease, infant mortality, development, humans, low birth weight, prenatal exposure delayed effects
412-417
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44
2007
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44
Abstract
Current orthodoxy states that coronary heart disease results from the unhealthy lifestyles of westernized adults together with a contribution from genetic inheritance. This does not provide a secure basis for prevention of the disease. Geographical studies gave the first clue that the disease originates during intra-uterine development. Variations in mortality from the disease across England and Wales were shown to correlate closely with past differences in death rates among newborn babies. In the past most deaths among newborns were attributed to low birthweight. This led to the hypothesis that undernutrition in utero permanently changes the body's structure, function and metabolism in ways that lead to coronary heart disease in later life. The association between low birthweight and coronary heart disease has been confirmed in longitudinal studies of men and women around the world. The developmental model of the origins of the disease offers a new way forward
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Published date: 2007
Keywords:
epidemiology, life style, pregnancy, male, wales, infant, origins, metabolism, coronary disease, disease, heart, physiopathology, england and wales, physiology, in-utero, fetal development, newborn, england, etiology, mortality, hypothesis, function, female, social conditions, review, fetal nutrition disorders, undernutrition, women, longitudinal studies, adult, coronary heart disease, infant mortality, development, humans, low birth weight, prenatal exposure delayed effects
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Local EPrints ID: 60888
URI: http://eprints.soton.ac.uk/id/eprint/60888
ISSN: 1365-2796
PURE UUID: 4d435db9-2931-415e-b23d-b1f1db157df0
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Date deposited: 12 Sep 2008
Last modified: 15 Mar 2024 11:21
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D.J. Barker
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