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Pre-morbid intelligence, the metabolic syndrome and mortality: the Vietnam experience study

Pre-morbid intelligence, the metabolic syndrome and mortality: the Vietnam experience study
Pre-morbid intelligence, the metabolic syndrome and mortality: the Vietnam experience study
Aims/Hypothesis: We examined the relationship between pre-morbid intelligence quotient (IQ) and the metabolic syndrome, and assessed the role of the metabolic syndrome as a mediating factor in the association of IQ with total and cardiovascular disease (CVD) mortality.

Methods: In this cohort study, 4,157 men with IQ test results from late adolescence or early adulthood [mean age (range) 20.4 (16-30) years] attended a clinical examination in middle-age [38.3 (31-46) years] at which the components of the metabolic syndrome were measured. They were then followed for 15 years to assess mortality.

Results: In age-adjusted analyses, IQ was significantly inversely related to four of the five individual components comprising the metabolic syndrome: hypertension, high BMI, high triglycerides and high blood glucose, but not low HDL-cholesterol. After controlling for a range of covariates that included socioeconomic position, higher IQ scores were associated with a reduced prevalence of the metabolic syndrome itself (odds ratio(1 SD increase in IQ) 0.87, 95% CI 0.78-0.98). Structural equation modelling revealed that education was not a mediator of the relationship between IQ and the metabolic syndrome. The metabolic syndrome partially mediated the relationship between IQ and CVD but not that between IQ and total mortality.

Conclusions/Interpretation: In this cohort, higher scores on a pre-morbid IQ test were associated with a lower prevalence of the metabolic syndrome and most of its components. The metabolic syndrome was a mediating variable in the IQ-CVD relationship.
cardiovascular disease, cvd, intelligence quotient, iq, metabolic syndrome, mortality, socioeconomic position
0012-186X
436-443
Batty, G.D.
bf322937-2cfb-4174-b5cb-dc016f0d0b8a
Gale, C.R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Mortensen, L.H.
053a4abd-af2e-486e-8e5e-5e2dedae259c
Langenberg, C.
cdc40a90-cb96-42fa-855b-8a2bef402282
Shipley, M.J.
da07ad9b-1ea2-41f9-8c2a-df67edd60a70
Deary, I.J.
e3403cfe-eb5b-4941-903d-87ef0db89c60
Batty, G.D.
bf322937-2cfb-4174-b5cb-dc016f0d0b8a
Gale, C.R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Mortensen, L.H.
053a4abd-af2e-486e-8e5e-5e2dedae259c
Langenberg, C.
cdc40a90-cb96-42fa-855b-8a2bef402282
Shipley, M.J.
da07ad9b-1ea2-41f9-8c2a-df67edd60a70
Deary, I.J.
e3403cfe-eb5b-4941-903d-87ef0db89c60

Batty, G.D., Gale, C.R., Mortensen, L.H., Langenberg, C., Shipley, M.J. and Deary, I.J. (2008) Pre-morbid intelligence, the metabolic syndrome and mortality: the Vietnam experience study. Diabetologia, 51 (3), 436-443. (doi:10.1007/s00125-007-0908-5).

Record type: Article

Abstract

Aims/Hypothesis: We examined the relationship between pre-morbid intelligence quotient (IQ) and the metabolic syndrome, and assessed the role of the metabolic syndrome as a mediating factor in the association of IQ with total and cardiovascular disease (CVD) mortality.

Methods: In this cohort study, 4,157 men with IQ test results from late adolescence or early adulthood [mean age (range) 20.4 (16-30) years] attended a clinical examination in middle-age [38.3 (31-46) years] at which the components of the metabolic syndrome were measured. They were then followed for 15 years to assess mortality.

Results: In age-adjusted analyses, IQ was significantly inversely related to four of the five individual components comprising the metabolic syndrome: hypertension, high BMI, high triglycerides and high blood glucose, but not low HDL-cholesterol. After controlling for a range of covariates that included socioeconomic position, higher IQ scores were associated with a reduced prevalence of the metabolic syndrome itself (odds ratio(1 SD increase in IQ) 0.87, 95% CI 0.78-0.98). Structural equation modelling revealed that education was not a mediator of the relationship between IQ and the metabolic syndrome. The metabolic syndrome partially mediated the relationship between IQ and CVD but not that between IQ and total mortality.

Conclusions/Interpretation: In this cohort, higher scores on a pre-morbid IQ test were associated with a lower prevalence of the metabolic syndrome and most of its components. The metabolic syndrome was a mediating variable in the IQ-CVD relationship.

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More information

Published date: 2008
Keywords: cardiovascular disease, cvd, intelligence quotient, iq, metabolic syndrome, mortality, socioeconomic position

Identifiers

Local EPrints ID: 60899
URI: https://eprints.soton.ac.uk/id/eprint/60899
ISSN: 0012-186X
PURE UUID: cd8f1932-9529-445c-a4a7-aa75abcf54b2
ORCID for C.R. Gale: ORCID iD orcid.org/0000-0002-3361-8638

Catalogue record

Date deposited: 11 Sep 2008
Last modified: 14 Mar 2019 01:52

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Contributors

Author: G.D. Batty
Author: C.R. Gale ORCID iD
Author: L.H. Mortensen
Author: C. Langenberg
Author: M.J. Shipley
Author: I.J. Deary

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