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Mid-facial anthropometry in second-trimester fetuses with trisomy 21: a three-dimensional ultrasound study

Record type: Article

Objectives: The aim of this study was to evaluate whether fetuses with trisomy 21 and detectable nasal bones have a distinct facial anthropometry that can be objectively defined using three-dimensional (3D) ultrasonography.
Methods: A prospective cross-sectional study of 40 fetuses in the second trimester, 17 with trisomy 21 and 23 controls, was performed. The 3D volume datasets of each case were evaluated for documentation of the nasal bones using the multiplanar and the maximum mode. The nasal bone length and the angle formed by the two maxillary bones at the level of the frontal process were then measured.
Results: The nasal bones were absent in 7 (41%) of the 17 fetuses with Down syndrome. All of the 23 normal fetuses had detectable nasal bones. The difference between nasal bone length in trisomy 21 fetuses and controls did not reach statistical significance (p = 0.087). The mean maxillary angle in trisomy 21 fetuses with nasal bones was significantly wider compared to controls (p = 0.029).
Conclusions: The nasal bones are present in the majority of fetuses with trisomy 21 in the second trimester. This group of fetuses has a characteristic mid-facial anthropometry (wider maxillary angle) that can be assessed by means of 3D ultrasonography.

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Citation

Bergann, Anna, Bamberg, Christian, Eder, Katja, Proquitte, Hans, Hartung, John P., Bollmann, Rainer and Kalache, Karim D. (2006) Mid-facial anthropometry in second-trimester fetuses with trisomy 21: a three-dimensional ultrasound study Prenatal Diagnosis, 26, (2), pp. 158-162. (doi:10.1002/pd.1362).

More information

Published date: 6 February 2006
Keywords: nasal bones, maxilla, trisomy 22, three-dimensional, ultrasonography, prenatal diagnosis

Identifiers

Local EPrints ID: 60912
URI: http://eprints.soton.ac.uk/id/eprint/60912
ISSN: 0197-3851
PURE UUID: 0ea114ea-08b9-4c40-9ee1-f56ff8130eb2

Catalogue record

Date deposited: 23 Sep 2008
Last modified: 17 Jul 2017 14:23

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Contributors

Author: Anna Bergann
Author: Christian Bamberg
Author: Katja Eder
Author: Hans Proquitte
Author: John P. Hartung
Author: Rainer Bollmann
Author: Karim D. Kalache

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