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Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function

Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function
Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function
The perinatal environment is a powerful determinant of risk for developing disease in later life. Here, we have shown that maternal undernutrition causes dramatic changes in heart structure and hypothalamo-pituitary-adrenal (HPA) function across two generations. Pregnant guinea pigs were fed 70% of normal intake from gestational days 1-35 (early restriction; ER), or 36-70 (late restriction; LR). Female offspring (F(1)) were mated and fed ad libitum to create second generation (F(2)) offspring. Heart morphology, blood pressure, baroreceptor and HPA function were assessed in male F(1) and F(2) offspring. ER(F1) males exhibited elevated blood pressure, increased left ventricular (LV) wall thickness and LV mass. These LV effects were maintained in the ER(F2) offspring. Maternal undernutrition increased basal cortisol and altered HPA responsiveness to challenge in both generations; effects were greatest in LR groups. In conclusion, moderate maternal undernutrition profoundly modifies heart structure and HPA function in adult male offspring for two generations.
cortisol, guinea pigs, function, blood, later life, food deprivation, cardiovascular, health, blood pressure, heart, risk, origins, mass, physiology, maternal undernutrition, undernutrition, male, pituitary-adrenal system, disease, environment, pregnancy, research, pressure, animals, hypothalamo-hypophyseal system, adult, prenatal exposure delayed effects, blood-pressure, methods, prenatal nutrition physiology, female, caloric restriction, maternal
0022-3751
2217-2229
Bertram, Caroline
bd8d2058-c047-4dd6-a1f2-8191fcbe1b08
Khan, Omar
b0170e98-eb6b-44b9-b3b5-d9dd70b67850
Ohri, Sunil
8aa5698c-78cf-4f59-a5af-5afa46f0348c
Phillips, David I.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Matthews, Stephen G.
c014a3e1-757b-4727-b228-4554200e32f6
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Bertram, Caroline
bd8d2058-c047-4dd6-a1f2-8191fcbe1b08
Khan, Omar
b0170e98-eb6b-44b9-b3b5-d9dd70b67850
Ohri, Sunil
8aa5698c-78cf-4f59-a5af-5afa46f0348c
Phillips, David I.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Matthews, Stephen G.
c014a3e1-757b-4727-b228-4554200e32f6
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f

Bertram, Caroline, Khan, Omar, Ohri, Sunil, Phillips, David I., Matthews, Stephen G. and Hanson, Mark A. (2008) Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function. The Journal of Physiology, 586 (8), 2217-2229. (doi:10.1113/jphysiol.2007.147967).

Record type: Article

Abstract

The perinatal environment is a powerful determinant of risk for developing disease in later life. Here, we have shown that maternal undernutrition causes dramatic changes in heart structure and hypothalamo-pituitary-adrenal (HPA) function across two generations. Pregnant guinea pigs were fed 70% of normal intake from gestational days 1-35 (early restriction; ER), or 36-70 (late restriction; LR). Female offspring (F(1)) were mated and fed ad libitum to create second generation (F(2)) offspring. Heart morphology, blood pressure, baroreceptor and HPA function were assessed in male F(1) and F(2) offspring. ER(F1) males exhibited elevated blood pressure, increased left ventricular (LV) wall thickness and LV mass. These LV effects were maintained in the ER(F2) offspring. Maternal undernutrition increased basal cortisol and altered HPA responsiveness to challenge in both generations; effects were greatest in LR groups. In conclusion, moderate maternal undernutrition profoundly modifies heart structure and HPA function in adult male offspring for two generations.

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More information

Published date: 2008
Keywords: cortisol, guinea pigs, function, blood, later life, food deprivation, cardiovascular, health, blood pressure, heart, risk, origins, mass, physiology, maternal undernutrition, undernutrition, male, pituitary-adrenal system, disease, environment, pregnancy, research, pressure, animals, hypothalamo-hypophyseal system, adult, prenatal exposure delayed effects, blood-pressure, methods, prenatal nutrition physiology, female, caloric restriction, maternal
Organisations: Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 60915
URI: https://eprints.soton.ac.uk/id/eprint/60915
ISSN: 0022-3751
PURE UUID: 39a3f9b8-005b-4648-898d-2544e3cfb015
ORCID for Mark A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X

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Date deposited: 12 Sep 2008
Last modified: 14 Mar 2019 01:47

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Contributors

Author: Caroline Bertram
Author: Omar Khan
Author: Sunil Ohri
Author: David I. Phillips
Author: Stephen G. Matthews
Author: Mark A. Hanson ORCID iD

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