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Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function

Bertram, Caroline, Khan, Omar, Ohri, Sunil, Phillips, David I., Matthews, Stephen G. and Hanson, Mark A. (2008) Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function The Journal of Physiology, 586, (8), pp. 2217-2229. (doi:10.1113/jphysiol.2007.147967).

Record type: Article


The perinatal environment is a powerful determinant of risk for developing disease in later life. Here, we have shown that maternal undernutrition causes dramatic changes in heart structure and hypothalamo-pituitary-adrenal (HPA) function across two generations. Pregnant guinea pigs were fed 70% of normal intake from gestational days 1-35 (early restriction; ER), or 36-70 (late restriction; LR). Female offspring (F(1)) were mated and fed ad libitum to create second generation (F(2)) offspring. Heart morphology, blood pressure, baroreceptor and HPA function were assessed in male F(1) and F(2) offspring. ER(F1) males exhibited elevated blood pressure, increased left ventricular (LV) wall thickness and LV mass. These LV effects were maintained in the ER(F2) offspring. Maternal undernutrition increased basal cortisol and altered HPA responsiveness to challenge in both generations; effects were greatest in LR groups. In conclusion, moderate maternal undernutrition profoundly modifies heart structure and HPA function in adult male offspring for two generations.

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Published date: 2008
Keywords: cortisol, guinea pigs, function, blood, later life, food deprivation, cardiovascular, health, blood pressure, heart, risk, origins, mass, physiology, maternal undernutrition, undernutrition, male, pituitary-adrenal system, disease, environment, pregnancy, research, pressure, animals, hypothalamo-hypophyseal system, adult, prenatal exposure delayed effects, blood-pressure, methods, prenatal nutrition physiology, female, caloric restriction, maternal
Organisations: Dev Origins of Health & Disease


Local EPrints ID: 60915
ISSN: 0022-3751
PURE UUID: 39a3f9b8-005b-4648-898d-2544e3cfb015

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Date deposited: 12 Sep 2008
Last modified: 17 Jul 2017 14:23

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Author: Caroline Bertram
Author: Omar Khan
Author: Sunil Ohri
Author: David I. Phillips
Author: Stephen G. Matthews
Author: Mark A. Hanson

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