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Adult mesenchymal stem cells and impaction grafting: a new clinical paradigm shift

Adult mesenchymal stem cells and impaction grafting: a new clinical paradigm shift
Adult mesenchymal stem cells and impaction grafting: a new clinical paradigm shift
The demographic challenges of an increasingly aging population emphasize the need for innovative approaches to skeletal reconstruction to augment and repair skeletal tissue lost as a consequence of implant loosening, trauma, degeneration or in situations involving revision surgery requiring bone stock. These clinical imperatives to augment skeletal tissue loss have brought mesenchymal stem cells to the fore in combination with the emerging discipline of tissue engineering. To date, impaction bone grafting for revision hip surgery is a recognized technique to reconstitute bone utilizing morselized allograft to provide a good mechanical scaffold, although with little osteoinductive biological potential. This review details laboratory and clinical examples of a paradigm shift in the application of mesenchymal stem cells with allograft to produce a living composite using the principles of tissue engineering. This step change creates a composite that offers a biological and mechanical advantage over the current gold standard of allograft alone. This translation of tissue engineering concepts into clinical practice offers enormous input into the field of bone regeneration and has implications for translation and future change in skeletal orthopedic practice in an increasingly aging population
80 and over, hip, replacement, arthroplasty, aged, supply & distribution, therapeutic use, adult, origins, humans, bone transplantation, cytology, bone, mesenchymal stem cell transplantation, methods, bone regeneration, tissue engineering, aging, mesenchymal stem cells, bone substitutes, bone resorption, disease, review, research, health, stem cells, surgery
1743-4440
393-404
Bolland, B.J.
c8fd42ef-2524-4eaf-b1d4-10281cdedebb
Tilley, S.
ec56245c-4ddb-48fa-943c-a2ec11a92baf
New, A.M.
9f1266a8-dbc0-45ab-9954-06949015ab41
Dunlop, D.G.
5f8d8b5c-e516-48b8-831f-c6e5529a52cc
Oreffo, R.O.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Bolland, B.J.
c8fd42ef-2524-4eaf-b1d4-10281cdedebb
Tilley, S.
ec56245c-4ddb-48fa-943c-a2ec11a92baf
New, A.M.
9f1266a8-dbc0-45ab-9954-06949015ab41
Dunlop, D.G.
5f8d8b5c-e516-48b8-831f-c6e5529a52cc
Oreffo, R.O.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778

Bolland, B.J., Tilley, S., New, A.M., Dunlop, D.G. and Oreffo, R.O. (2007) Adult mesenchymal stem cells and impaction grafting: a new clinical paradigm shift. Expert Review of Medical Devices, 4 (3), 393-404.

Record type: Article

Abstract

The demographic challenges of an increasingly aging population emphasize the need for innovative approaches to skeletal reconstruction to augment and repair skeletal tissue lost as a consequence of implant loosening, trauma, degeneration or in situations involving revision surgery requiring bone stock. These clinical imperatives to augment skeletal tissue loss have brought mesenchymal stem cells to the fore in combination with the emerging discipline of tissue engineering. To date, impaction bone grafting for revision hip surgery is a recognized technique to reconstitute bone utilizing morselized allograft to provide a good mechanical scaffold, although with little osteoinductive biological potential. This review details laboratory and clinical examples of a paradigm shift in the application of mesenchymal stem cells with allograft to produce a living composite using the principles of tissue engineering. This step change creates a composite that offers a biological and mechanical advantage over the current gold standard of allograft alone. This translation of tissue engineering concepts into clinical practice offers enormous input into the field of bone regeneration and has implications for translation and future change in skeletal orthopedic practice in an increasingly aging population

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More information

Published date: 2007
Keywords: 80 and over, hip, replacement, arthroplasty, aged, supply & distribution, therapeutic use, adult, origins, humans, bone transplantation, cytology, bone, mesenchymal stem cell transplantation, methods, bone regeneration, tissue engineering, aging, mesenchymal stem cells, bone substitutes, bone resorption, disease, review, research, health, stem cells, surgery

Identifiers

Local EPrints ID: 60919
URI: https://eprints.soton.ac.uk/id/eprint/60919
ISSN: 1743-4440
PURE UUID: 239b6fc6-93f2-490f-b3c0-c2ebb118e673
ORCID for R.O. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 12 Sep 2008
Last modified: 20 Jul 2019 01:08

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Contributors

Author: B.J. Bolland
Author: S. Tilley
Author: A.M. New
Author: D.G. Dunlop
Author: R.O. Oreffo ORCID iD

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