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Docosahexaenoic acid is selectively enriched in plasma phospholipids during pregnancy in Trinidadian women--results of a pilot study

Docosahexaenoic acid is selectively enriched in plasma phospholipids during pregnancy in Trinidadian women--results of a pilot study
Docosahexaenoic acid is selectively enriched in plasma phospholipids during pregnancy in Trinidadian women--results of a pilot study
The fetal demand for docosahexaenoic acid (DHA) has to be satisfied by the mother. We determined the fatty acids in maternal plasma non-esterified fatty acid (NEFA), triacylglycerol (TAG) and phosphatidylcholine (PC), in a cross-sectional study of non-pregnant (n = 10), pregnant (n = 19), and postpartum (n = 9) women. There were lipid class-dependent differences in plasma polyunsaturated fatty acid (PUFA) concentrations between groups. During pregnancy, DHA was most highly enriched in PC, about 230%, with more modest enrichment for linoleic acid (LA) and arachidonic acid (AA), and no enrichment of alpha-linolenic acid (alpha-LNA). There was relative enrichment of LA, AA and alpha-LNA in TAG, but not of DHA. There was no specific enrichment of any PUFA in the NEFA pool. These data accord with the suggestion that the enrichment of alpha-LNA in TAG and of DHA in phospholipids reflects hepatic regulation of n-3 PUFA metabolism which potentially enhances the delivery of DHA to the placenta.
pregnancy, human, plasma, polyunsaturated fatty acid
0926-5287
63-67
Burdge, Graham C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Sherman, Rachel C.
921daee5-2de1-42b1-bc76-4cef6ad324b8
Ali, Zulaika
2f8163cc-c66f-41d6-97aa-5bd27c087897
Wootton, Stephen A.
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Jackson, Alan A.
c9a12d7c-b4d6-4c92-820e-890a688379ef
Burdge, Graham C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Sherman, Rachel C.
921daee5-2de1-42b1-bc76-4cef6ad324b8
Ali, Zulaika
2f8163cc-c66f-41d6-97aa-5bd27c087897
Wootton, Stephen A.
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Jackson, Alan A.
c9a12d7c-b4d6-4c92-820e-890a688379ef

Burdge, Graham C., Sherman, Rachel C., Ali, Zulaika, Wootton, Stephen A. and Jackson, Alan A. (2006) Docosahexaenoic acid is selectively enriched in plasma phospholipids during pregnancy in Trinidadian women--results of a pilot study. Reproduction, Nutrition, Development, 46 (1), 63-67. (doi:10.1051/rnd:2005061).

Record type: Article

Abstract

The fetal demand for docosahexaenoic acid (DHA) has to be satisfied by the mother. We determined the fatty acids in maternal plasma non-esterified fatty acid (NEFA), triacylglycerol (TAG) and phosphatidylcholine (PC), in a cross-sectional study of non-pregnant (n = 10), pregnant (n = 19), and postpartum (n = 9) women. There were lipid class-dependent differences in plasma polyunsaturated fatty acid (PUFA) concentrations between groups. During pregnancy, DHA was most highly enriched in PC, about 230%, with more modest enrichment for linoleic acid (LA) and arachidonic acid (AA), and no enrichment of alpha-linolenic acid (alpha-LNA). There was relative enrichment of LA, AA and alpha-LNA in TAG, but not of DHA. There was no specific enrichment of any PUFA in the NEFA pool. These data accord with the suggestion that the enrichment of alpha-LNA in TAG and of DHA in phospholipids reflects hepatic regulation of n-3 PUFA metabolism which potentially enhances the delivery of DHA to the placenta.

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More information

Published date: 2006
Keywords: pregnancy, human, plasma, polyunsaturated fatty acid

Identifiers

Local EPrints ID: 60939
URI: http://eprints.soton.ac.uk/id/eprint/60939
ISSN: 0926-5287
PURE UUID: 75d478d9-631a-4efb-8e4c-d9387cf4a7bb
ORCID for Graham C. Burdge: ORCID iD orcid.org/0000-0002-7665-2967

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Date deposited: 23 Sep 2008
Last modified: 14 Jun 2024 17:25

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Contributors

Author: Rachel C. Sherman
Author: Zulaika Ali
Author: Alan A. Jackson

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