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The effect of altering the 20:5n-3 and 22:6n-3 content of a meal on the postprandial incorporation of n-3 polyunsaturated fatty acids into plasma triacylglycerol and non-esterified fatty acids in humans

Burdge, G.C., Sala-Vila, A., West, A.L., Robson, H.J.L., Le Fevre, L.W., Powell, J. and Calder, P.C. (2007) The effect of altering the 20:5n-3 and 22:6n-3 content of a meal on the postprandial incorporation of n-3 polyunsaturated fatty acids into plasma triacylglycerol and non-esterified fatty acids in humans Prostaglandins, Leukotrienes and Essential Fatty Acids, 77, (1), pp. 59-65. (doi:10.1016/j.plefa.2007.06.003).

Record type: Article

Abstract

Previous studies suggest that consuming meals containing large amounts of fish oil is associated with selective postprandial incorporation of 20:5n-3 and 22:6n-3 into plasma non-esterified fatty acids (NEFA). We investigated the effect of consuming meals containing different amounts of 20:5n-3 and 22:6n-3 comparable to dietary habits of western populations on the postprandial incorporation of 18:3n-3, 20:5n-3 and 22:6n-3 into plasma triacylglycerol (TAG) and NEFA over 6h in middle aged subjects. 20:5n-3 incorporation into plasma TAG was greater than 22:6n-3 irrespective of the test meal. Conversely, 22:6n-3 incorporation into plasma NEFA was greater than 20:5n-3, irrespective of the test meal. There was no effect of the amount of 20:5n-3+22:6n-3 in the test meal on the 18:3n-3 incorporation into plasma TAG or NEFA. These findings suggest differential metabolism of 20:5n-3 and 22:6n-3 in the postprandial period when consumed in amounts typical of western dietary habits.

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More information

Published date: 10 August 2007
Keywords: humans, male, aged, human, nutrition, postprandial period, metabolism, blood, middle aged, nonesterified, analysis, docosahexaenoic acids, fatty acids, administration & dosage, triglycerides, time factors, acid, female, eicosapentaenoic acid, sex factors, physiology

Identifiers

Local EPrints ID: 60944
URI: http://eprints.soton.ac.uk/id/eprint/60944
ISSN: 0952-3278
PURE UUID: c96c0142-1637-4f23-8752-399dd2f44520
ORCID for G.C. Burdge: ORCID iD orcid.org/0000-0002-7665-2967
ORCID for A.L. West: ORCID iD orcid.org/0000-0002-3331-0684

Catalogue record

Date deposited: 23 Sep 2008
Last modified: 17 Jul 2017 14:22

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Contributors

Author: G.C. Burdge ORCID iD
Author: A. Sala-Vila
Author: A.L. West ORCID iD
Author: H.J.L. Robson
Author: L.W. Le Fevre
Author: J. Powell
Author: P.C. Calder

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