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Sex, but not maternal protein or folic acid intake, determines the fatty acid composition of hepatic phospholipids, but not of triacylglycerol, in adult rats

Sex, but not maternal protein or folic acid intake, determines the fatty acid composition of hepatic phospholipids, but not of triacylglycerol, in adult rats
Sex, but not maternal protein or folic acid intake, determines the fatty acid composition of hepatic phospholipids, but not of triacylglycerol, in adult rats
The aim of the study was to investigate whether the protein and folic acid content of the maternal diet and the sex of the offspring alter the polyunsaturated fatty acid content of hepatic phospholipids and triacylglycerol (TAG). Pregnant rats were fed diets containing 18% or 9% protein with either 1 or 5mg/kg folic acid. Maternal diet did not alter hepatic lipid composition in the adult offspring. Data from each maternal dietary group were combined and reanalysed. The proportion of 18:0, 20:4n-6 and 22:6n-3 in liver phospholipids was higher in females than in males, while hepatic TAG composition did not differ between sexes. Delta5 Desaturase expression was higher in females than in males. Neither Delta5 nor Delta6 desaturase expression was related to polyunsaturated fatty acid concentrations. These results suggest that sex differences in liver phospholipid fatty acid composition may reflect primary differences in the specificity of phospholipid biosynthesis.
73-79
Burdge, G.C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Slater-Jefferies, J.L.
e46c711a-9d4c-436a-b853-828df69bb4d7
Grant, R.A.
cdd20d0e-aa0f-41a1-9e93-b828abe8d3d7
Chung, W.S.
e2fb3bf0-ca67-4d33-b19a-ae68e9648a51
West, A.L.
c1923242-802f-4331-b743-31de45d3883c
Lillycrop, K.A.
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Burdge, G.C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Slater-Jefferies, J.L.
e46c711a-9d4c-436a-b853-828df69bb4d7
Grant, R.A.
cdd20d0e-aa0f-41a1-9e93-b828abe8d3d7
Chung, W.S.
e2fb3bf0-ca67-4d33-b19a-ae68e9648a51
West, A.L.
c1923242-802f-4331-b743-31de45d3883c
Lillycrop, K.A.
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6

Burdge, G.C., Slater-Jefferies, J.L., Grant, R.A., Chung, W.S., West, A.L., Lillycrop, K.A., Hanson, M.A. and Calder, P.C. (2008) Sex, but not maternal protein or folic acid intake, determines the fatty acid composition of hepatic phospholipids, but not of triacylglycerol, in adult rats. Prostaglandins, Leukotrienes and Essential Fatty Acids, 78 (1), 73-79. (doi:10.1016/j.plefa.2007.10.028).

Record type: Article

Abstract

The aim of the study was to investigate whether the protein and folic acid content of the maternal diet and the sex of the offspring alter the polyunsaturated fatty acid content of hepatic phospholipids and triacylglycerol (TAG). Pregnant rats were fed diets containing 18% or 9% protein with either 1 or 5mg/kg folic acid. Maternal diet did not alter hepatic lipid composition in the adult offspring. Data from each maternal dietary group were combined and reanalysed. The proportion of 18:0, 20:4n-6 and 22:6n-3 in liver phospholipids was higher in females than in males, while hepatic TAG composition did not differ between sexes. Delta5 Desaturase expression was higher in females than in males. Neither Delta5 nor Delta6 desaturase expression was related to polyunsaturated fatty acid concentrations. These results suggest that sex differences in liver phospholipid fatty acid composition may reflect primary differences in the specificity of phospholipid biosynthesis.

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Published date: January 2008

Identifiers

Local EPrints ID: 60949
URI: https://eprints.soton.ac.uk/id/eprint/60949
PURE UUID: c2cfda2f-f882-42e3-8340-be7233e48b08
ORCID for G.C. Burdge: ORCID iD orcid.org/0000-0002-7665-2967
ORCID for A.L. West: ORCID iD orcid.org/0000-0002-3331-0684
ORCID for K.A. Lillycrop: ORCID iD orcid.org/0000-0001-7350-5489
ORCID for M.A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X

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Date deposited: 30 Sep 2008
Last modified: 14 Mar 2019 01:54

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Contributors

Author: G.C. Burdge ORCID iD
Author: R.A. Grant
Author: W.S. Chung
Author: A.L. West ORCID iD
Author: K.A. Lillycrop ORCID iD
Author: M.A. Hanson ORCID iD
Author: P.C. Calder

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