The University of Southampton
University of Southampton Institutional Repository

The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumption

The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumption
The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumption
The nutritional cues which induce different phenotypes from a single genotype in developing offspring are poorly understood. How well prenatal nutrient availability before birth predicts that after birth may also determine the offspring's response to later metabolic challenge. We investigated the effect of feeding pregnant rats diets containing protein at 180 g/kg (Control) or 90 g/kg (protein-restricted, PR) and either 1 or 5 mg folic acid/kg on growth and metabolic response to fasting in their offspring, and also the effect of diets with different fat contents (40 g/kg (Fat(4)) or 100 g/kg (Fat(10))) after weaning. Offspring of dams fed the PR diet with 5 mg/kg folic acid were significantly lighter than other offspring. The PR offspring fed the Fat(4) diet had lower plasma TAG than the Control offspring, but this relationship was reversed when offspring were fed Fat(10). Increasing the folic acid content of the Control or PR maternal diets induced opposing effects on plasma TAG, NEFA, beta-hydroxybutyrate and glucose concentrations in offspring fed Fat(4). The effect was accentuated in offspring fed the Fat(10) diet such that these metabolites were increased in the Control offspring, but reduced in the PR offspring. These data show for the first time that maternal dietary folic acid intake alters offspring phenotype depending upon dietary protein intake, and that this effect is modified by fat intake after weaning. Prevention by increased folic acid intake of an altered metabolic phenotype by maternal protein-restriction may be at the expense of somatic growth.
body weight, pregnancy, blood, heart, birth, human, rats, proteins, prenatal nutrition physiology, metabolism, physiology, liver, lactation, prenatal exposure delayed effects, growth, phenotype, pregnant rats, nutrition, lipids, dietary fats, time, folic acid, weaning, protein, rat, research, genotype, glucose, anatomy & histology, diet, organ size, female, acid, cues, animals, male, maternal, plasma, eating, blood glucose, fasting, dietary proteins, administration & dosage
0007-1145
540-549
Burdge, Graham C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Lillycrop, Karen A.
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Jackson, Alan A.
c9a12d7c-b4d6-4c92-820e-890a688379ef
Gluckman, Peter D.
ef2e8b92-0b76-4a12-bd7c-01b0674f94d3
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Burdge, Graham C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Lillycrop, Karen A.
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Jackson, Alan A.
c9a12d7c-b4d6-4c92-820e-890a688379ef
Gluckman, Peter D.
ef2e8b92-0b76-4a12-bd7c-01b0674f94d3
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f

Burdge, Graham C., Lillycrop, Karen A., Jackson, Alan A., Gluckman, Peter D. and Hanson, Mark A. (2008) The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumption. British Journal of Nutrition, 99 (3), 540-549. (doi:10.1017/S0007114507815819).

Record type: Article

Abstract

The nutritional cues which induce different phenotypes from a single genotype in developing offspring are poorly understood. How well prenatal nutrient availability before birth predicts that after birth may also determine the offspring's response to later metabolic challenge. We investigated the effect of feeding pregnant rats diets containing protein at 180 g/kg (Control) or 90 g/kg (protein-restricted, PR) and either 1 or 5 mg folic acid/kg on growth and metabolic response to fasting in their offspring, and also the effect of diets with different fat contents (40 g/kg (Fat(4)) or 100 g/kg (Fat(10))) after weaning. Offspring of dams fed the PR diet with 5 mg/kg folic acid were significantly lighter than other offspring. The PR offspring fed the Fat(4) diet had lower plasma TAG than the Control offspring, but this relationship was reversed when offspring were fed Fat(10). Increasing the folic acid content of the Control or PR maternal diets induced opposing effects on plasma TAG, NEFA, beta-hydroxybutyrate and glucose concentrations in offspring fed Fat(4). The effect was accentuated in offspring fed the Fat(10) diet such that these metabolites were increased in the Control offspring, but reduced in the PR offspring. These data show for the first time that maternal dietary folic acid intake alters offspring phenotype depending upon dietary protein intake, and that this effect is modified by fat intake after weaning. Prevention by increased folic acid intake of an altered metabolic phenotype by maternal protein-restriction may be at the expense of somatic growth.

Full text not available from this repository.

More information

e-pub ahead of print date: 29 August 2007
Published date: March 2008
Keywords: body weight, pregnancy, blood, heart, birth, human, rats, proteins, prenatal nutrition physiology, metabolism, physiology, liver, lactation, prenatal exposure delayed effects, growth, phenotype, pregnant rats, nutrition, lipids, dietary fats, time, folic acid, weaning, protein, rat, research, genotype, glucose, anatomy & histology, diet, organ size, female, acid, cues, animals, male, maternal, plasma, eating, blood glucose, fasting, dietary proteins, administration & dosage

Identifiers

Local EPrints ID: 60950
URI: https://eprints.soton.ac.uk/id/eprint/60950
ISSN: 0007-1145
PURE UUID: f985d3e1-2b6a-49f4-8d69-7adaf4c7e302
ORCID for Graham C. Burdge: ORCID iD orcid.org/0000-0002-7665-2967
ORCID for Karen A. Lillycrop: ORCID iD orcid.org/0000-0001-7350-5489
ORCID for Mark A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X

Catalogue record

Date deposited: 09 Sep 2008
Last modified: 19 Nov 2019 02:01

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×