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The carotid bodies influence growth responses to moderate maternal undernutrition in late-gestation fetal sheep

The carotid bodies influence growth responses to moderate maternal undernutrition in late-gestation fetal sheep
The carotid bodies influence growth responses to moderate maternal undernutrition in late-gestation fetal sheep
OBJECTIVE: To determine the role of carotid sinus innervation on differential fetal organ growth during maternal nutrient restriction in late pregnancy. DESIGN: Randomised controlled study. SETTING: University research facility. SAMPLE: Thirty-nine Merino ewes. METHODS: At 113 days gestational age (dGA), fetuses were bilaterally carotid sinus denervated or sham denervated. From 118 dGA, the surgery groups were subdivided into two dietary groups, and their ewes were fed 100% of nutrient requirements or 50% until tissue collection at 140 dGA. This provided four groups (sham/control diet, sham/restricted diet, denervated/control diet and denervated/restricted diet). MAIN OUTCOME MEASURES: Fetal organ weights and hormone levels and maternal weight change during the dietary restriction. RESULTS: Adrenal glands were larger in sham/restricted diet fetuses than in sham/control diet or denervated/restricted diet fetuses (P < 0.05). Fetal adrenal weight and brain-to-liver weight ratio were positively related to maternal weight change during the nutritional challenge in sham fetuses only (P < 0.05). Fetal liver weight was negatively related to maternal weight change during nutritional challenge in sham fetuses only (P < 0.05). CONCLUSIONS: We have shown a reduction in liver growth but sparing of adrenal growth in response to moderate maternal undernutrition, which is dependent on intact carotid body innervation. This suggests a new role for the carotid bodies in the control of differential organ growth during such undernutrition
physiology, maternal undernutrition, etiology, responses, innervation, fetal blood, fetal sheep, embryology, body weight, chemistry, random allocation, research, fetal development, methods, disease, pregnancy complications, gestational age, growth, weight, reducing, health, diet, blood, undernutrition, adverse effects, metabolism, electrolytes, lung, hydrocortisone, liver, developmental origins, fetal, animals, surgery, sheep, organ size, brain, insulin, maternal, origins, pregnancy, female, malnutrition, adrenal glands, carotid sinus, adrenocorticotropic hormone
1470-0328
261-268
Burrage, D.
05d88d5b-209f-465d-a8c9-cd0d87ce89a8
Green, L.R.
8a601974-efe5-4916-9268-9e7bc72d89c5
Moss, T.J.
5f50aa2b-82ee-40e8-8752-71cba74794d4
Sloboda, D.M.
b8d482da-5bb0-4e84-9123-835402a49c63
Nitsos, I.
fa39186c-6745-4e13-b6b6-108a9b640ff0
Newnham, J.P.
43ed7def-0e99-47c9-b907-5154b7206186
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Burrage, D.
05d88d5b-209f-465d-a8c9-cd0d87ce89a8
Green, L.R.
8a601974-efe5-4916-9268-9e7bc72d89c5
Moss, T.J.
5f50aa2b-82ee-40e8-8752-71cba74794d4
Sloboda, D.M.
b8d482da-5bb0-4e84-9123-835402a49c63
Nitsos, I.
fa39186c-6745-4e13-b6b6-108a9b640ff0
Newnham, J.P.
43ed7def-0e99-47c9-b907-5154b7206186
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f

Burrage, D., Green, L.R., Moss, T.J., Sloboda, D.M., Nitsos, I., Newnham, J.P. and Hanson, M.A. (2008) The carotid bodies influence growth responses to moderate maternal undernutrition in late-gestation fetal sheep. BJOG: An International Journal of Obstetrics & Gynaecology, 115 (2), 261-268. (doi:10.1111/j.1471-0528.2007.01607.x).

Record type: Article

Abstract

OBJECTIVE: To determine the role of carotid sinus innervation on differential fetal organ growth during maternal nutrient restriction in late pregnancy. DESIGN: Randomised controlled study. SETTING: University research facility. SAMPLE: Thirty-nine Merino ewes. METHODS: At 113 days gestational age (dGA), fetuses were bilaterally carotid sinus denervated or sham denervated. From 118 dGA, the surgery groups were subdivided into two dietary groups, and their ewes were fed 100% of nutrient requirements or 50% until tissue collection at 140 dGA. This provided four groups (sham/control diet, sham/restricted diet, denervated/control diet and denervated/restricted diet). MAIN OUTCOME MEASURES: Fetal organ weights and hormone levels and maternal weight change during the dietary restriction. RESULTS: Adrenal glands were larger in sham/restricted diet fetuses than in sham/control diet or denervated/restricted diet fetuses (P < 0.05). Fetal adrenal weight and brain-to-liver weight ratio were positively related to maternal weight change during the nutritional challenge in sham fetuses only (P < 0.05). Fetal liver weight was negatively related to maternal weight change during nutritional challenge in sham fetuses only (P < 0.05). CONCLUSIONS: We have shown a reduction in liver growth but sparing of adrenal growth in response to moderate maternal undernutrition, which is dependent on intact carotid body innervation. This suggests a new role for the carotid bodies in the control of differential organ growth during such undernutrition

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Published date: 2008
Keywords: physiology, maternal undernutrition, etiology, responses, innervation, fetal blood, fetal sheep, embryology, body weight, chemistry, random allocation, research, fetal development, methods, disease, pregnancy complications, gestational age, growth, weight, reducing, health, diet, blood, undernutrition, adverse effects, metabolism, electrolytes, lung, hydrocortisone, liver, developmental origins, fetal, animals, surgery, sheep, organ size, brain, insulin, maternal, origins, pregnancy, female, malnutrition, adrenal glands, carotid sinus, adrenocorticotropic hormone
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Identifiers

Local EPrints ID: 60951
URI: http://eprints.soton.ac.uk/id/eprint/60951
DOI: doi:10.1111/j.1471-0528.2007.01607.x
ISSN: 1470-0328
PURE UUID: 15a04149-af15-48ba-8df4-4bd8d10d128a
ORCID for L.R. Green: ORCID iD orcid.org/0000-0001-7423-9696
ORCID for M.A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X

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Date deposited: 04 Sep 2008
Last modified: 16 Mar 2024 03:19

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Contributors

Author: D. Burrage
Author: L.R. Green ORCID iD
Author: T.J. Moss
Author: D.M. Sloboda
Author: I. Nitsos
Author: J.P. Newnham
Author: M.A. Hanson ORCID iD

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