Sex and twinning influence early gestation undernutrition effects on sheep offspring growth
Sex and twinning influence early gestation undernutrition effects on sheep offspring growth
Objectives: Multiple pregnancy affects size at birth and
growth pattern from as early as 8 weeks gestation (Iffy et
al., 1983. Am. J. Obstet. Gynecol. 146, 970—972). Male
embryos grow at a greater rate than females (Pedersen,
1980. Br. Med. J. 281, 1253). We hypothesised that
moderate maternal undernutrion in early gestation will
have a greater effect on male offspring growth, particularly
if combined with the increased constraint of being a twin.
Methods: Welsh Mountain ewes received 100% (C, n =41) or
50% nutrient requirements (U, n =47) from 1 to 31 days
gestation (dGA), and 100% thereafter. Ewes were weighed
weekly and blood samples were collected at 1, 30, and 65
dGA for cortisol analysis (Immulite analyser, DPC).
Results: At day 31, U ewes had gained less weight than C
ewes and had a lower plasma cortisol concentration
( p b0.05). During 1—31 dGA, twin bearing ewes gained less
weight than singleton bearing ewes. At birth, twins were
smaller than singleton lambs ( p b0.05). Weight gained
between birth and 12 weeks old and weight at 12 weeks
old were greater in U males compared to C males, an effect
that was predominantly in twins ( p b0.01). Data were
analysed by ANOVA.
Conclusion: The increased constraint of being a twin and a
male embryo in a nutrient-restricted intrauterine environment
induces a phenotype more likely to gain weight in a
good postnatal environment.
Supported by the British Heart Foundation.
time, sheep, england, undernutrition, growth
p.550
Cleal, J.K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Poore, K.R.
b9529ba3-6432-4935-b8fd-6e382f11f0ad
Newman, J.P.
38b6cc7a-a882-40fd-a03a-388aae18416d
Noakes, D.
cabb514c-5582-4f0e-a756-704c6e30a633
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Green, L.R.
8a601974-efe5-4916-9268-9e7bc72d89c5
August 2006
Cleal, J.K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Poore, K.R.
b9529ba3-6432-4935-b8fd-6e382f11f0ad
Newman, J.P.
38b6cc7a-a882-40fd-a03a-388aae18416d
Noakes, D.
cabb514c-5582-4f0e-a756-704c6e30a633
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Green, L.R.
8a601974-efe5-4916-9268-9e7bc72d89c5
Cleal, J.K., Poore, K.R., Newman, J.P., Noakes, D., Hanson, M.A. and Green, L.R.
(2006)
Sex and twinning influence early gestation undernutrition effects on sheep offspring growth.
Early Human Development, 82 (8), .
Record type:
Meeting abstract
Abstract
Objectives: Multiple pregnancy affects size at birth and
growth pattern from as early as 8 weeks gestation (Iffy et
al., 1983. Am. J. Obstet. Gynecol. 146, 970—972). Male
embryos grow at a greater rate than females (Pedersen,
1980. Br. Med. J. 281, 1253). We hypothesised that
moderate maternal undernutrion in early gestation will
have a greater effect on male offspring growth, particularly
if combined with the increased constraint of being a twin.
Methods: Welsh Mountain ewes received 100% (C, n =41) or
50% nutrient requirements (U, n =47) from 1 to 31 days
gestation (dGA), and 100% thereafter. Ewes were weighed
weekly and blood samples were collected at 1, 30, and 65
dGA for cortisol analysis (Immulite analyser, DPC).
Results: At day 31, U ewes had gained less weight than C
ewes and had a lower plasma cortisol concentration
( p b0.05). During 1—31 dGA, twin bearing ewes gained less
weight than singleton bearing ewes. At birth, twins were
smaller than singleton lambs ( p b0.05). Weight gained
between birth and 12 weeks old and weight at 12 weeks
old were greater in U males compared to C males, an effect
that was predominantly in twins ( p b0.01). Data were
analysed by ANOVA.
Conclusion: The increased constraint of being a twin and a
male embryo in a nutrient-restricted intrauterine environment
induces a phenotype more likely to gain weight in a
good postnatal environment.
Supported by the British Heart Foundation.
This record has no associated files available for download.
More information
Published date: August 2006
Additional Information:
Abstracts of the 4th World Congress on Developmental Origins of Health and Disease (DOHaD), 13–16 September 2006, Educatorium, University of Utrecht, The Netherlands (H-08)
Keywords:
time, sheep, england, undernutrition, growth
Organisations:
Medicine
Identifiers
Local EPrints ID: 60994
URI: http://eprints.soton.ac.uk/id/eprint/60994
ISSN: 0378-3782
PURE UUID: 6243df5b-a147-4660-8fcf-dd8153f57671
Catalogue record
Date deposited: 29 Sep 2008
Last modified: 16 Mar 2024 03:29
Export record
Contributors
Author:
J.P. Newman
Author:
D. Noakes
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
