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The effect of acute maternal hypoglycaemia on fetal cardiovascular control

Cleal, J.K., Hanson, M.A., Gardiner, H.M. and Green, L.R. (2007) The effect of acute maternal hypoglycaemia on fetal cardiovascular control Early Human Development, 83, (supplement 1), p.S88. (doi:10.1016/S0378-3782(07)70191-3).

Record type: Article


Aims: To investigate the effect of acute maternal hypoglycaemia on fetal cardiovascular (CV) function, as a sub-optimal environment in utero has been implicated in the development of CV disease in adult life.
Subjects: Fetal sheep (n = 7) were studied in utero at 125 and 126 days gestational age (dGA, term = 147 days) following implantation of vascular catheters and an umbilical cord occluder at 119 dGA.
Study design: Fetal CV parameters were measured during a maternal saline (day 125) and insulin (day 125) infusion. Fetal CV function was assessed by: (a) generating a dose response curve to angiotensin II; (b) a 90 sec total umbilical cord occlusion; (c) administration of phenylephrine to assess baroreflex function.
Outcome measures: (a) Area under the mean arterial blood pressure (MAP) response (AUC) to increasing doses of angiotensin II; (b) MAP and heart rate (HR) response to cord occlusion; (c) sensitivity and operating point of the baroreflex response. Results: Maternal insulin infusion resulted in maternal and fetal hypoglycaemia. (a) The angiotensin II MAP AUC was not affected by hypoglycaemia. (b) The increase in MAP and decrease in HR following a 90 sec cord occlusion was not affected by hypoglycaemia. (c) Hypoglycaemia resulted in reduced fetal baroreflex sensitivity (P <0.05, paired t test).
Conclusions: Our finding of reduced fetal baroreflex sensitivity during fetal hypoglycaemia indicates altered CV homeostatic mechanisms. Such fetal adaptations to a poor intrauterine environment could contribute towards the development of altered cardiovascular phenotype in adult life.

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Published date: September 2007
Additional Information: 5th International Congress on Developmental Origins of Health & Disease (Poster P1-21)
Keywords: cardiovascular, fetal, maternal


Local EPrints ID: 60998
ISSN: 0378-3782
PURE UUID: e3d6f33c-662c-4423-bde0-b0df7238f34b
ORCID for L.R. Green: ORCID iD

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Date deposited: 29 Sep 2008
Last modified: 17 Jul 2017 14:22

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Author: J.K. Cleal
Author: M.A. Hanson
Author: H.M. Gardiner
Author: L.R. Green ORCID iD

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