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The effect of acute maternal hypoglycaemia on fetal cardiovascular control

Record type: Article

Aims: To investigate the effect of acute maternal hypoglycaemia on fetal cardiovascular (CV) function, as a sub-optimal environment in utero has been implicated in the development of CV disease in adult life.
Subjects: Fetal sheep (n = 7) were studied in utero at 125 and 126 days gestational age (dGA, term = 147 days) following implantation of vascular catheters and an umbilical cord occluder at 119 dGA.
Study design: Fetal CV parameters were measured during a maternal saline (day 125) and insulin (day 125) infusion. Fetal CV function was assessed by: (a) generating a dose response curve to angiotensin II; (b) a 90 sec total umbilical cord occlusion; (c) administration of phenylephrine to assess baroreflex function.
Outcome measures: (a) Area under the mean arterial blood pressure (MAP) response (AUC) to increasing doses of angiotensin II; (b) MAP and heart rate (HR) response to cord occlusion; (c) sensitivity and operating point of the baroreflex response. Results: Maternal insulin infusion resulted in maternal and fetal hypoglycaemia. (a) The angiotensin II MAP AUC was not affected by hypoglycaemia. (b) The increase in MAP and decrease in HR following a 90 sec cord occlusion was not affected by hypoglycaemia. (c) Hypoglycaemia resulted in reduced fetal baroreflex sensitivity (P <0.05, paired t test).
Conclusions: Our finding of reduced fetal baroreflex sensitivity during fetal hypoglycaemia indicates altered CV homeostatic mechanisms. Such fetal adaptations to a poor intrauterine environment could contribute towards the development of altered cardiovascular phenotype in adult life.

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Citation

Cleal, J.K., Hanson, M.A., Gardiner, H.M. and Green, L.R. (2007) The effect of acute maternal hypoglycaemia on fetal cardiovascular control Early Human Development, 83, (supplement 1), p.S88. (doi:10.1016/S0378-3782(07)70191-3).

More information

Published date: September 2007
Additional Information: 5th International Congress on Developmental Origins of Health & Disease (Poster P1-21)
Keywords: cardiovascular, fetal, maternal

Identifiers

Local EPrints ID: 60998
URI: http://eprints.soton.ac.uk/id/eprint/60998
ISSN: 0378-3782
PURE UUID: e3d6f33c-662c-4423-bde0-b0df7238f34b
ORCID for L.R. Green: ORCID iD orcid.org/0000-0001-7423-9696

Catalogue record

Date deposited: 29 Sep 2008
Last modified: 17 Jul 2017 14:22

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Contributors

Author: J.K. Cleal
Author: M.A. Hanson
Author: H.M. Gardiner
Author: L.R. Green ORCID iD

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