The mechanisms and regulation of placental amino acid transport to the human foetus
The mechanisms and regulation of placental amino acid transport to the human foetus
The mechanisms by which amino acids are transferred across the human placenta are fundamental to our understanding of foetal nutrition. Amino acid transfer across the human placenta is dependent on transport across both the microvillous and basal plasma membranes of the placental syncytiotrophoblast, and on metabolism within the syncytiotrophoblast. Although the principles underlying uptake of amino acids across the microvillous plasma membrane are well understood, the extent to which amino acids are metabolised within human placenta and the mechanisms by which amino acids are transported out of the placenta across the basal plasma membrane are not well understood. Understanding the mechanisms and regulation of amino acid transport is necessary to understand the causes of intrauterine growth restriction in human pregnancy.
amino acid, placenta, transport, foetus, metabolism
419-426
Cleal, J.K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Lewis, R.M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
April 2008
Cleal, J.K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Lewis, R.M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Cleal, J.K. and Lewis, R.M.
(2008)
The mechanisms and regulation of placental amino acid transport to the human foetus.
Journal of Neuroendocrinology, 20 (4), .
(doi:10.1111/j.1365-2826.2008.01662.x).
Abstract
The mechanisms by which amino acids are transferred across the human placenta are fundamental to our understanding of foetal nutrition. Amino acid transfer across the human placenta is dependent on transport across both the microvillous and basal plasma membranes of the placental syncytiotrophoblast, and on metabolism within the syncytiotrophoblast. Although the principles underlying uptake of amino acids across the microvillous plasma membrane are well understood, the extent to which amino acids are metabolised within human placenta and the mechanisms by which amino acids are transported out of the placenta across the basal plasma membrane are not well understood. Understanding the mechanisms and regulation of amino acid transport is necessary to understand the causes of intrauterine growth restriction in human pregnancy.
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Published date: April 2008
Keywords:
amino acid, placenta, transport, foetus, metabolism
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Local EPrints ID: 61001
URI: http://eprints.soton.ac.uk/id/eprint/61001
ISSN: 0953-8194
PURE UUID: 824667bd-d23a-47a8-bf23-cf78c06dc779
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Date deposited: 25 Sep 2008
Last modified: 16 Mar 2024 03:23
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