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Propogation of the vasodilator response assessed by full-field laser doppler perfusion imaging (FLPI): a new fast tissue blood flow imaging technique

Record type: Article

We have previously used high resolution scanning laser Doppler imaging [LDI] to quantify spatial and temporal changes in vascular perfusion following dermal provocation with vasoactive mediators [Clough et al., B J Dermatol 1998;138:806-814]. We used the LDI in repeat mode with scans of 30 sec duration and ?4000 pixel density, giving a spatial resolution of ?0.6 mm² per pixel over an area of 5 x 5 cm². Peak responses were seen within 2-3 min of agonist administration. These studies also reveal heterogeneity of perfusion response that was suggestive of selective recruitment of vessels in relation to the underlying dermal vasculature architecture. We have now explored this further using FLPI: this imaging technique was used at frame rates between 5 Hz and 0.2 Hz and spatial resolutions between 0.017 and 0.52 mm² per pixel over areas of 2 x 2.7 cm² and 6.7 x 9 cm², respectively. Preliminary results suggest that the rate of the linear phase of the increase in blood flux adjacent to the site of provocation is of the order of 1.8 PU [laser Doppler perfusion units]/sec. At more distant sites [17 mm] blood flux appears to rise more slowly [0.6 PU/sec at] with a latency of between 20 – 40 sec. Peak responses were seen within 3 minutes of provocation. The propagation of the dilatation response away from the site of provocation was of the order of 0.5 mm/sec. The FLPI imager is now being used to explore further the development of the vasodilator response in healthy skin in order to study both normal physiological mechanisms and the mechanisms underlying pathological skin disorders in which the microvasculature plays a predominant role.

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Citation

Clough, G.F., Church, M.K., Gush, R.J., Somers, M.C.S and Boggett, D.M. (2006) Propogation of the vasodilator response assessed by full-field laser doppler perfusion imaging (FLPI): a new fast tissue blood flow imaging technique Journal of Vascular Research, 43, (Supplement 1), p.38. (doi:10.1159/000094939).

More information

Published date: 2006
Additional Information: Poster Session: PMI.3
Keywords: blood-flow, blood flow, blood

Identifiers

Local EPrints ID: 61003
URI: http://eprints.soton.ac.uk/id/eprint/61003
ISSN: 1018-1172
PURE UUID: acc821dc-0b3f-45bd-a2a1-fae528a0d62b
ORCID for G.F. Clough: ORCID iD orcid.org/0000-0002-6226-8964

Catalogue record

Date deposited: 18 Nov 2008
Last modified: 17 Jul 2017 14:22

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Contributors

Author: G.F. Clough ORCID iD
Author: M.K. Church
Author: R.J. Gush
Author: M.C.S Somers
Author: D.M. Boggett

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