Antibiotic hypersensitivity mimicking recurrent endocarditis--identifying the culprit with the in vitro lymphocyte transformation test
Antibiotic hypersensitivity mimicking recurrent endocarditis--identifying the culprit with the in vitro lymphocyte transformation test
The drug hypersensitivity syndrome is characterized by fever and systemic abnormalities including lymphopenia, lymphadenopathy, skin and visceral involvement mimicking systemic sepsis. The following case illustrates how the in vitro lymphocyte transformation test can be used to confirm drug hypersensitivity in this scenario, differentiating it from deteriorating infective endocarditis, hence avoiding progression to inappropriate interventions.
diagnosis, in-vitro, lymphocyte activation, letter, etiology, differential, male, anti-bacterial agents, middle aged, report, endocarditis, humans, adverse effects, recurrence, case report, drug hypersensitivity, prevention & control
67-68
Cooper, H.L.
80852309-f99f-4024-a4d7-71ba0342261a
Pickard, C.
e21117b3-6345-4d09-a876-ac9965ec4d6a
Healy, E.
400fc04d-f81a-474a-ae25-7ff894be0ebd
Friedmann, P.S.
d50bac23-f3ec-4493-8fa0-fa126cbeba88
Foley, P.W.
d7d41fd1-95b4-40dc-9284-1f37ae6ac861
Morgan, J.M.
e1a187e2-3fae-414d-86b6-dfe336ec94f9
2008
Cooper, H.L.
80852309-f99f-4024-a4d7-71ba0342261a
Pickard, C.
e21117b3-6345-4d09-a876-ac9965ec4d6a
Healy, E.
400fc04d-f81a-474a-ae25-7ff894be0ebd
Friedmann, P.S.
d50bac23-f3ec-4493-8fa0-fa126cbeba88
Foley, P.W.
d7d41fd1-95b4-40dc-9284-1f37ae6ac861
Morgan, J.M.
e1a187e2-3fae-414d-86b6-dfe336ec94f9
Cooper, H.L., Pickard, C., Healy, E., Friedmann, P.S., Foley, P.W. and Morgan, J.M.
(2008)
Antibiotic hypersensitivity mimicking recurrent endocarditis--identifying the culprit with the in vitro lymphocyte transformation test.
QJM: An International Journal of Medicine, 101 (1), .
(doi:10.1093/qjmed/hcm107).
Abstract
The drug hypersensitivity syndrome is characterized by fever and systemic abnormalities including lymphopenia, lymphadenopathy, skin and visceral involvement mimicking systemic sepsis. The following case illustrates how the in vitro lymphocyte transformation test can be used to confirm drug hypersensitivity in this scenario, differentiating it from deteriorating infective endocarditis, hence avoiding progression to inappropriate interventions.
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Published date: 2008
Keywords:
diagnosis, in-vitro, lymphocyte activation, letter, etiology, differential, male, anti-bacterial agents, middle aged, report, endocarditis, humans, adverse effects, recurrence, case report, drug hypersensitivity, prevention & control
Identifiers
Local EPrints ID: 61019
URI: http://eprints.soton.ac.uk/id/eprint/61019
ISSN: 1460-2725
PURE UUID: e9c9f464-c4d2-437e-8aef-00880ba601eb
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Date deposited: 10 Sep 2008
Last modified: 15 Mar 2024 11:21
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Contributors
Author:
H.L. Cooper
Author:
C. Pickard
Author:
P.S. Friedmann
Author:
P.W. Foley
Author:
J.M. Morgan
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