The University of Southampton
University of Southampton Institutional Repository

Hypothalamic-pituitary-adrenal axis activity in adults who were prenatally exposed to the Dutch famine

Record type: Article

OBJECTIVE: The hypothalamic-pituitary-adrenal (HPA) axis has been proposed to be susceptible to fetal programming, the process by which an adverse fetal environment elicits permanent physiological and metabolic alterations predisposing to disease in later life. It is hypothesized that fetal exposure to poor circumstances alters the set point of the HPA axis, leading to increased HPA axis activity and subsequent increased cortisol concentrations. In this study, we tested the hypothesis that prenatal exposure to famine during different periods of gestation is associated with increased activity of the HPA axis.
DESIGN AND METHODS: We assessed plasma cortisol concentrations after a dexamethasone suppression and an ACTH1-24 -stimulation test in a group of 98 men and women randomly sampled from the Dutch famine birth cohort. Cohort members were born as term singletons around the 1944-1945 Dutch famine.
RESULTS: Cortisol profiles after dexamethasone suppression and ACTH1-24 stimulation were similar for participants exposed to famine during late, mid- or early gestation (P = 0.78). Cortisol concentrations after dexamethasone suppression test did not differ between those exposed and those unexposed to famine in utero (mean difference -2% (95% confidence interval (CI) -27 to 23)). Neither peak cortisol concentration (20 nmol/l (95% CI -27 to 66)), cortisol increment (-5 nmol/l (95% CI -56 to 47)) or cortisol area under the curve post-ACTH1-24 injection (4% (95% CI -4 to 12)) differed between exposed and unexposed participants.
CONCLUSIONS: Prenatal famine exposure does not seem to affect HPA axis activity at adult age, at least not at the adrenal level. This does not exclude altered HPA axis activity at the levels of the hippocampus and hypothalamus.

Full text not available from this repository.

Citation

De Rooij, Susanne R., Painter, Rebecca C., Phillips, David I., Osmond, Clive, Michels, Robert P., Bossuyt, Patrick M., Bleker, Otto P. and Roseboom, Tessa J. (2006) Hypothalamic-pituitary-adrenal axis activity in adults who were prenatally exposed to the Dutch famine European Journal of Endocrinology, 155, (1), pp. 153-160.

More information

Published date: 2006
Additional Information: nonValidatingUrl:doi:10.1530/eje.1.02193
Keywords: birth, methods, programming, fetal, men, in-utero, environment, plasma, dexamethasone, later life, fetal programming, cardiovascular disease, hypothesis, exposure, cohort, cortisol, disease, activity, women, adult

Identifiers

Local EPrints ID: 61049
URI: http://eprints.soton.ac.uk/id/eprint/61049
ISSN: 0804-4643
PURE UUID: 1bdde3fe-b37b-47a1-b697-15105e870a2e
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 12 Sep 2008
Last modified: 17 Jul 2017 14:22

Export record

Contributors

Author: Susanne R. De Rooij
Author: Rebecca C. Painter
Author: David I. Phillips
Author: Clive Osmond ORCID iD
Author: Robert P. Michels
Author: Patrick M. Bossuyt
Author: Otto P. Bleker
Author: Tessa J. Roseboom

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×