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Lipid profile, obesity and bone mineral density: the Hertfordshire cohort study

Dennison, E.M., Syddall, H.E., Aihie Sayer, A., Martin, H.J. and Cooper, C. (2007) Lipid profile, obesity and bone mineral density: the Hertfordshire cohort study QJM: An International Journal of Medicine, 100, (5), pp. 297-303. (doi:10.1093/qjmed/hcm023).

Record type: Article


BACKGROUND: Body mass index (BMI) and bone mineral density (BMD) are positively correlated in several studies, but few data relate bone density, lipid profile and anthropometric measures. AIM: To investigate these relationships in a large, well-characterized cohort of men and women (The Hertfordshire Cohort Study).
METHODS: Men (n = 465) and women (n = 448) from Hertfordshire, UK were recruited. Information was available on demographic and lifestyle factors, anthropometric measurements, body fat percentage, fasting triglycerides, cholesterol (total, HDL, LDL), apolipoprotein (a) and apolipoprotein (b); bone mineral density (BMD) was recorded at the lumbar spine and total femur.
RESULTS: BMD at the lumbar spine (males r = 0.15, p = 0.001; females r = 0.14, p = 0.003) and total femoral region (males r = 0.18, p = 0.0001; females r = 0.16, p = 0.0008) was related to serum triglyceride level, even after adjustment for waist-hip ratio, age, social class and lifestyle factors, but not if body fat percentage was substituted for waist-hip ratio in the regression model. Fasting HDL cholesterol level was related to lumbar spine BMD in women (r = -0.15, p = 0.001) and total femoral BMD in both sexes (males r = -0.15, p = 0.002; females r = -0.23, p < 0.0001); these relationships were also attenuated by adjustment for body fat percentage but not waist-hip ratio. No relationships were seen between total or LDL cholesterol with BMD.
DISCUSSION: In this cohort, relationships between lipid profile and BMD were robust to adjustment for one measure of central obesity (waist-hip ratio), but not total body fat. This broadly supports the idea that adiposity may confound the relationship between lipids and bone mass.

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Published date: 2007
Keywords: methods, social class, lipids, bone density, obesity, male, female, body mass index, bone, cohort studies, waist-hip ratio, cohort, triglycerides, Hertfordshire, bone mass, women, fasting, cholesterol, femur


Local EPrints ID: 61062
ISSN: 1460-2725
PURE UUID: f9020051-6ccf-4db4-9dd4-4c2bde0d492b
ORCID for H.E. Syddall: ORCID iD
ORCID for C. Cooper: ORCID iD

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Date deposited: 10 Sep 2008
Last modified: 17 Jul 2017 14:22

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Author: E.M. Dennison
Author: H.E. Syddall ORCID iD
Author: A. Aihie Sayer
Author: H.J. Martin
Author: C. Cooper ORCID iD

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