Edwards, C.J. and Arden, N.K.
Commentary: statins and fracture--why the confusion?
International Journal of Epidemiology, 35, (5), . (doi:10.1093/ije/dyl137).
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In 1999 a paper published in Science suggested that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) increased bone formation in rodents by effects on a potent bone forming cytokine bone morphogenetic protein-2 (BMP-2).1 Subsequent studies have suggested that statins increase bone mineral density (BMD) in humans2 and have investigated whether statin use is associated with reduced fracture risk.
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