Commentary: statins and fracture--why the confusion?

Edwards, C.J. and Arden, N.K. (2006) Commentary: statins and fracture--why the confusion? International Journal of Epidemiology, 35, (5), pp. 1312-1313. (doi:10.1093/ije/dyl137).


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In 1999 a paper published in Science suggested that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) increased bone formation in rodents by effects on a potent bone forming cytokine bone morphogenetic protein-2 (BMP-2).1 Subsequent studies have suggested that statins increase bone mineral density (BMD) in humans2 and have investigated whether statin use is associated with reduced fracture risk.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1093/ije/dyl137
ISSNs: 0300-5771 (print)
Keywords: editorial, nosp, bone
ePrint ID: 61070
Date :
Date Event
Date Deposited: 08 Sep 2008
Last Modified: 16 Apr 2017 17:31
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