Long-chain n-3 fatty acid supplementation in men increases resistance to activated protein C
Long-chain n-3 fatty acid supplementation in men increases resistance to activated protein C
It has recently and controversially been demonstrated that fish oil supplementation may not be beneficial for everyone, but to date there have been no biological explanations. We suggest that resistance to the anticoagulant, activated protein C (APC), be considered as a potential mechanism, because it has been demonstrated that the type of fatty acids on phospholipids modulates function of the APC pathway. The APC ratio in plasma was decreased by 7% after fish oil supplementation in healthy men (P<.005; n=35). The decrease in APC ratio equates to an increase in APC resistance. Fish oil lowered the APC ratio by (1) increasing low-density lipoprotein (LDL) cholesterol (P<.01) and apolipoprotein B (P<.05) and (2) increasing platelet microparticles (P<.05). In vitro, purified LDL decreased the APC ratio and increased microparticle formation. These changes affecting the anticoagulant APC could contribute toward a prothrombotic state, potentially explaining the recent observation that fish oil supplementation may not always be of benefit. These findings will need to be repeated in different disease states.
547-551
Englyst, Nicola A.
f84399af-7265-4224-b556-102c3aa272b0
Grimble, Robert F.
3100e4d2-8f29-4ca6-a95d-38a6a764865f
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
April 2007
Englyst, Nicola A.
f84399af-7265-4224-b556-102c3aa272b0
Grimble, Robert F.
3100e4d2-8f29-4ca6-a95d-38a6a764865f
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Englyst, Nicola A., Grimble, Robert F. and Byrne, Christopher D.
(2007)
Long-chain n-3 fatty acid supplementation in men increases resistance to activated protein C.
Metabolism, 56 (4), .
(doi:10.1016/j.metabol.2006.11.017).
Abstract
It has recently and controversially been demonstrated that fish oil supplementation may not be beneficial for everyone, but to date there have been no biological explanations. We suggest that resistance to the anticoagulant, activated protein C (APC), be considered as a potential mechanism, because it has been demonstrated that the type of fatty acids on phospholipids modulates function of the APC pathway. The APC ratio in plasma was decreased by 7% after fish oil supplementation in healthy men (P<.005; n=35). The decrease in APC ratio equates to an increase in APC resistance. Fish oil lowered the APC ratio by (1) increasing low-density lipoprotein (LDL) cholesterol (P<.01) and apolipoprotein B (P<.05) and (2) increasing platelet microparticles (P<.05). In vitro, purified LDL decreased the APC ratio and increased microparticle formation. These changes affecting the anticoagulant APC could contribute toward a prothrombotic state, potentially explaining the recent observation that fish oil supplementation may not always be of benefit. These findings will need to be repeated in different disease states.
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Published date: April 2007
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Local EPrints ID: 61093
URI: http://eprints.soton.ac.uk/id/eprint/61093
ISSN: 0026-0495
PURE UUID: b2b938a7-15d4-42ef-b1bc-150fcdb13de0
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Date deposited: 24 Sep 2008
Last modified: 16 Mar 2024 03:14
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Author:
Robert F. Grimble
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