The University of Southampton
University of Southampton Institutional Repository

Long-chain n-3 fatty acid supplementation in men increases resistance to activated protein C

Englyst, Nicola A., Grimble, Robert F. and Byrne, Christopher D. (2007) Long-chain n-3 fatty acid supplementation in men increases resistance to activated protein C Metabolism, 56, (4), pp. 547-551. (doi:10.1016/j.metabol.2006.11.017).

Record type: Article


It has recently and controversially been demonstrated that fish oil supplementation may not be beneficial for everyone, but to date there have been no biological explanations. We suggest that resistance to the anticoagulant, activated protein C (APC), be considered as a potential mechanism, because it has been demonstrated that the type of fatty acids on phospholipids modulates function of the APC pathway. The APC ratio in plasma was decreased by 7% after fish oil supplementation in healthy men (P<.005; n=35). The decrease in APC ratio equates to an increase in APC resistance. Fish oil lowered the APC ratio by (1) increasing low-density lipoprotein (LDL) cholesterol (P<.01) and apolipoprotein B (P<.05) and (2) increasing platelet microparticles (P<.05). In vitro, purified LDL decreased the APC ratio and increased microparticle formation. These changes affecting the anticoagulant APC could contribute toward a prothrombotic state, potentially explaining the recent observation that fish oil supplementation may not always be of benefit. These findings will need to be repeated in different disease states.

Full text not available from this repository.

More information

Published date: April 2007


Local EPrints ID: 61093
ISSN: 0026-0495
PURE UUID: b2b938a7-15d4-42ef-b1bc-150fcdb13de0

Catalogue record

Date deposited: 24 Sep 2008
Last modified: 17 Jul 2017 14:22

Export record



Author: Robert F. Grimble

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.