Insulin gene variable number of tandem repeats genotype, early growth and glucose metabolism in adult life
Insulin gene variable number of tandem repeats genotype, early growth and glucose metabolism in adult life
The predisposition to type 2 diabetes is programmed early in life and genotypes promoting survival during nutritional adversity could increase the risk of type 2 diabetes. The insulin gene and variation in the insulin gene variable number of tandem repeats (VNTR) polymorphism has been suggested to modify birth size and diabetes susceptibility.
Materials and Methods: We assessed the association between the insulin gene VNTR genotypes, early growth and glucose and insulin metabolismin adult life in 488 subjects participating in the Helsinki Birth Cohort Study.
Results: Body size at birth did not differ significantly between the INS VNTR genotypes. One additional type III allele was associated with a 13 g decrease (95% CI -55 to 81 g; p=0.7) in birthweight. Fasting glucose concentration was highest in the carriers of the III/III genotype. The cumulative incidence of type 2 diabetes did not differ between the genotypes. Interactions between birth size and insulin VNTR genotype in relation to fasting glucose (p for interaction =0.08 for birth weight, p=0.05 for birth length) and 2-hour insulin (p for interaction =0.04) were observed.
Conclusions: These interactions between body size at birth and genotype reflect interactions between the insulin VNTR gene and the intrauterine environment. Our findings are consistent with the hypothesis of developmental plasticity, where one genotype can give rise to different phenotypes dependent on the early environment.
insulin, growth, cardiovascular disease, glucose, gene, genotype, glucose metabolism, insulin resistance, metabolism, adult
180-187
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Forsen, T.
009ce53c-8bbf-4c5c-a21f-0bbdd1f999c4
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44
Laakso, M.
ec6734f9-b924-430e-89a0-47fa5c66110d
2006
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Forsen, T.
009ce53c-8bbf-4c5c-a21f-0bbdd1f999c4
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44
Laakso, M.
ec6734f9-b924-430e-89a0-47fa5c66110d
Eriksson, J.G., Osmond, C., Forsen, T., Kajantie, E., Barker, D.J. and Laakso, M.
(2006)
Insulin gene variable number of tandem repeats genotype, early growth and glucose metabolism in adult life.
Journal of Pediatric Endocrinology and Metabolism, 4, .
Abstract
The predisposition to type 2 diabetes is programmed early in life and genotypes promoting survival during nutritional adversity could increase the risk of type 2 diabetes. The insulin gene and variation in the insulin gene variable number of tandem repeats (VNTR) polymorphism has been suggested to modify birth size and diabetes susceptibility.
Materials and Methods: We assessed the association between the insulin gene VNTR genotypes, early growth and glucose and insulin metabolismin adult life in 488 subjects participating in the Helsinki Birth Cohort Study.
Results: Body size at birth did not differ significantly between the INS VNTR genotypes. One additional type III allele was associated with a 13 g decrease (95% CI -55 to 81 g; p=0.7) in birthweight. Fasting glucose concentration was highest in the carriers of the III/III genotype. The cumulative incidence of type 2 diabetes did not differ between the genotypes. Interactions between birth size and insulin VNTR genotype in relation to fasting glucose (p for interaction =0.08 for birth weight, p=0.05 for birth length) and 2-hour insulin (p for interaction =0.04) were observed.
Conclusions: These interactions between body size at birth and genotype reflect interactions between the insulin VNTR gene and the intrauterine environment. Our findings are consistent with the hypothesis of developmental plasticity, where one genotype can give rise to different phenotypes dependent on the early environment.
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Published date: 2006
Keywords:
insulin, growth, cardiovascular disease, glucose, gene, genotype, glucose metabolism, insulin resistance, metabolism, adult
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Local EPrints ID: 61098
URI: http://eprints.soton.ac.uk/id/eprint/61098
ISSN: 0334-018X
PURE UUID: c1fcd561-b1f4-4d29-a2b3-fc63f0a274b0
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Date deposited: 10 Sep 2008
Last modified: 23 Jul 2022 01:39
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Author:
J.G. Eriksson
Author:
T. Forsen
Author:
E. Kajantie
Author:
D.J. Barker
Author:
M. Laakso
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