The effect of sports injury on Insulin-like growth factor-I and Type 3 Procollagen: implications for detection of growth hormone abuse in athletes

Erotokritou-Mulligan, I., Bassett, E.E., Bartlett, C., Cowan, D., McHugh, C., Seah, R., Curtis, B., Wells, V., Harrison, K., Sonksen, P.H. and Holt, R.I. (2008) The effect of sports injury on Insulin-like growth factor-I and Type 3 Procollagen: implications for detection of growth hormone abuse in athletes. Journal of Clinical Endocrinology & Metabolism, 93 (7), 2760-2763. (doi:10.1210/jc.2007-2801).

Abstract

Context: A method to detect exogenously administered growth hormone (GH) based on the measurement of two GH-dependent markers, IGF-I and type 3 procollagen (P-III-P) has been proposed. Skeletal or soft tissue injury may alter these markers. Elevations in either of these proteins after injury might lead to a false accusation of doping with GH. Objective: The objective of the study was to assess the effect of musculoskeletal or soft tissue injury on IGF-I and P-III-P concentrations in amateur and elite athletes and assess the effect of injury on the proposed GH detection method. Design: This was a longitudinal observational study after sporting injury.

Setting: The study was conducted at Southampton General Hospital and British Olympic Medical Centre. Subjects: Subjects included elite and amateur athletes after an injury. Intervention: Interventions included measurement of IGF-I and P-III-P and application of the GH-2000 discriminant function score up to 84 d after an injury as well as classification of injury by type and severity. Outcome Measures: IGF-I and P-III-P concentration and ability to detect GH abuse in athletes without the risk of false accusation because of an injury were measured.

Results: There was no change in IGF-I concentration after an injury. By contrast, P-III-P concentrations rose by 41.1 +/- 16.6%, reaching a peak around 14 d after an injury. The rise in P-III-P varied according to injury type and severity. This rise had a trivial effect on the GH-2000 discriminant function score, and no subject reached the threshold needed for a doping offense.

Conclusions: Although there was a rise in P-III-P after injury, this was insufficient to invalidate the GH-2000 detection method based on IGF-I and P-III-P concentrations.

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Contributors

Author: R.I. Holt

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