Maternal diet during pregnancy and carotid intima-media thickness in children

Gale, Catharine R., Jiang, Benyu, Robinson, Sian M., Godfrey, Keith M., Law, Catherine M. and Martyn, Christopher N. (2006) Maternal diet during pregnancy and carotid intima-media thickness in children Arteriosclerosis, Thrombosis, and Vascular Biology, 26, (8), pp. 1877-1882. (doi:10.1161/01.ATV.0000228819.13039.b8).


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OBJECTIVE: Autopsy studies show that intimal lipid accumulations in arteries are often present at birth, suggesting that the prenatal environment plays a role in the pathogenesis of atherosclerosis. In animal models, a restricted or unbalanced maternal diet during gestation can influence susceptibility to atherosclerosis, but the relation in humans between maternal diet during pregnancy and atherogenesis is unknown. METHODS AND RESULTS: We measured carotid intima-media thickness (IMT) in 216 nine-year-old children whose mothers had participated in a study of nutrition during pregnancy. IMT was greater in boys, in children who were heavier, in those with higher systolic blood pressure, and in those who took less exercise. Increased IMT was associated with a lower maternal energy intake in early (P=0.029) or late (P=0.006) pregnancy, after adjustment for these factors. Mean IMT of children whose mothers were in the lowest quarter of the distribution of energy intake in late pregnancy was 0.027 mm (95% confidence interval, 0.004 to 0.049) greater than that of those whose mothers were in the highest quarter of the distribution. CONCLUSIONS: Lower maternal energy intake during pregnancy may increase the susceptibility to atherogenesis of the child.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1161/01.ATV.0000228819.13039.b8
ISSNs: 1079-5642 (print)
ePrint ID: 61122
Date :
Date Event
1 August 2006Published
Date Deposited: 30 Mar 2009
Last Modified: 16 Apr 2017 17:31
Further Information:Google Scholar

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