Avery, M.R., Voegeli, D. and Clough, G.F.
A signal processing approach to the invetiation of the effects of age and smoking history on microvascular function
Journal of Vascular Research, 43, (Supplement 1), . (doi:10.1159/000094939).
Full text not available from this repository.
We have used laser Doppler fluximetry [LDF] and signal processing to
investigate the effects of smoking on microvascular function. Skin blood
flux was measured using a pin-head probe [Moor Instruments, UK]
mounted in a 1 cm heating block before and during mild thermal
warming to 43 °C, in 8 heavy smokers [mean 50 y;19 cigarettes/day,30
pack years], 20 light smokers [23 y;11/day,4 pack years] and their age,
sex and BMI matched non-smoking controls. Basal LDF analysed in the
time domain was similar in all 4 groups[10–15 AU]. The increase in
blood flux during the initial 10 min heating was attenuated in both light
and heavy smokers vs controls [P<0.005]. Total hyperaemic response
[AUC to 10 min] was also significantly attenuated in the heavy smokers
[4 ± 2 vs 6 ± 2 x104 AU·sec] but not in the light smokers [8 ± 2 vs 10 ±
4]. The LDF trace was analysed in the frequency domain using a fast
Fourier transform and total spectral power together with the contribution
of the frequency intervals between 0.01 and 2 Hz, calculated.
Attenuation of the hyperaemic response in the heavy smokers was
associated with a reduction in total spectral power of >40%, attributable
to a reduction in spectral power around 0.01 Hz and 0.1 Hz [P<0.05].
These data suggest that the attenuation of the sustained hyperaemic
response to thermal warming in long-term smokers is associated with a
reduction in vasomotion and that this is in part the result of a reduced
endothelial and smooth muscle cell activity. These changes are also
evident in younger smokers with a shorter smoking history, suggesting
that the vasodilatory response is impaired even at this early stage.
Actions (login required)