A signal processing approach to the invetiation of the effects of age and smoking history on microvascular function

Avery, M.R., Voegeli, D. and Clough, G.F. (2006) A signal processing approach to the invetiation of the effects of age and smoking history on microvascular function Journal of Vascular Research, 43, (Supplement 1), p.47. (doi:10.1159/000094939).


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We have used laser Doppler fluximetry [LDF] and signal processing to investigate the effects of smoking on microvascular function. Skin blood flux was measured using a pin-head probe [Moor Instruments, UK] mounted in a 1 cm heating block before and during mild thermal warming to 43 °C, in 8 heavy smokers [mean 50 y;19 cigarettes/day,30 pack years], 20 light smokers [23 y;11/day,4 pack years] and their age, sex and BMI matched non-smoking controls. Basal LDF analysed in the time domain was similar in all 4 groups[10–15 AU]. The increase in blood flux during the initial 10 min heating was attenuated in both light and heavy smokers vs controls [P<0.005]. Total hyperaemic response [AUC to 10 min] was also significantly attenuated in the heavy smokers [4 ± 2 vs 6 ± 2 x104 AU·sec] but not in the light smokers [8 ± 2 vs 10 ± 4]. The LDF trace was analysed in the frequency domain using a fast Fourier transform and total spectral power together with the contribution of the frequency intervals between 0.01 and 2 Hz, calculated. Attenuation of the hyperaemic response in the heavy smokers was associated with a reduction in total spectral power of >40%, attributable to a reduction in spectral power around 0.01 Hz and 0.1 Hz [P<0.05]. These data suggest that the attenuation of the sustained hyperaemic response to thermal warming in long-term smokers is associated with a reduction in vasomotion and that this is in part the result of a reduced endothelial and smooth muscle cell activity. These changes are also evident in younger smokers with a shorter smoking history, suggesting that the vasodilatory response is impaired even at this early stage.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1159/000094939
Additional Information: 24th Conference of the European Society for Microcirculation: Poster Session – PSF 2
ISSNs: 1018-1172 (print)
Related URLs:
Keywords: smoking, function

ePrint ID: 61139
Date :
Date Event
August 2006Published
Date Deposited: 31 Mar 2009
Last Modified: 16 Apr 2017 17:31
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/61139

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