Developmental plasticity and human disease: research directions
Developmental plasticity and human disease: research directions
The conceptual basis of the 'developmental origins' paradigm has converged on the role of developmental plasticity responding to signals from the early environment, with heightened risk of disease if the induced phenotype does not match the later environment. Nevertheless, numerous questions remain, including the current burden of disease that can be attributed to early environmental factors; the pathways, mechanisms and windows of plasticity; the identification of early markers of environmentally induced change; and the feasibility, costs and benefits of intervention. A focused agenda of research is needed to convince policy makers of the importance of developmental factors in human disease.
fetal growth retardation, insulin resistance, leptin, obesity, pregnancy, type 2 diabetes mellitus
461-471
Gluckman, P.D.
492295c0-ef71-4871-ad5a-771c98e1059a
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
May 2007
Gluckman, P.D.
492295c0-ef71-4871-ad5a-771c98e1059a
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Gluckman, P.D. and Hanson, M.A.
(2007)
Developmental plasticity and human disease: research directions.
Journal of Internal Medicine, 261 (5), .
(doi:10.1111/j.1365-2796.2007.01802.x).
Abstract
The conceptual basis of the 'developmental origins' paradigm has converged on the role of developmental plasticity responding to signals from the early environment, with heightened risk of disease if the induced phenotype does not match the later environment. Nevertheless, numerous questions remain, including the current burden of disease that can be attributed to early environmental factors; the pathways, mechanisms and windows of plasticity; the identification of early markers of environmentally induced change; and the feasibility, costs and benefits of intervention. A focused agenda of research is needed to convince policy makers of the importance of developmental factors in human disease.
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Published date: May 2007
Keywords:
fetal growth retardation, insulin resistance, leptin, obesity, pregnancy, type 2 diabetes mellitus
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Local EPrints ID: 61154
URI: http://eprints.soton.ac.uk/id/eprint/61154
ISSN: 0954-6820
PURE UUID: b0abf8f8-4e03-4320-8a21-b595b465118c
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Date deposited: 25 Sep 2008
Last modified: 16 Mar 2024 03:17
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Author:
P.D. Gluckman
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