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Developmental plasticity and human disease: research directions

Gluckman, P.D. and Hanson, M.A. (2007) Developmental plasticity and human disease: research directions Journal of Internal Medicine, 261, (5), pp. 461-471. (doi:10.1111/j.1365-2796.2007.01802.x).

Record type: Article


The conceptual basis of the 'developmental origins' paradigm has converged on the role of developmental plasticity responding to signals from the early environment, with heightened risk of disease if the induced phenotype does not match the later environment. Nevertheless, numerous questions remain, including the current burden of disease that can be attributed to early environmental factors; the pathways, mechanisms and windows of plasticity; the identification of early markers of environmentally induced change; and the feasibility, costs and benefits of intervention. A focused agenda of research is needed to convince policy makers of the importance of developmental factors in human disease.

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Published date: May 2007
Keywords: fetal growth retardation, insulin resistance, leptin, obesity, pregnancy, type 2 diabetes mellitus


Local EPrints ID: 61154
ISSN: 0954-6820
PURE UUID: b0abf8f8-4e03-4320-8a21-b595b465118c

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Date deposited: 25 Sep 2008
Last modified: 17 Jul 2017 14:22

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