Non-genomic transgenerational inheritance of disease risk
Non-genomic transgenerational inheritance of disease risk
That there is a heritable or familial component of susceptibility to chronic non-communicable diseases such as type 2 diabetes, obesity and cardiovascular disease is well established, but there is increasing evidence that some elements of such heritability are transmitted non-genomically and that the processes whereby environmental influences act during early development to shape disease risk in later life can have effects beyond a single generation. Such heritability may operate through epigenetic mechanisms involving regulation of either imprinted or non-imprinted genes but also through broader mechanisms related to parental physiology or behaviour. We review evidence and potential mechanisms for non-genomic transgenerational inheritance of 'lifestyle' disease and propose that the 'developmental origins of disease' phenomenon is a maladaptive consequence of an ancestral mechanism of developmental plasticity that may have had adaptive value in the evolution of generalist species such as Homo sapiens
cardiovascular-disease, origins, epigenetic, cardiovascular, heritable, prenatal exposure delayed effects, diabetes, growth, pregnancy, research, etiology, developmental plasticity, genetic, physiology, female, cardiovascular disease, genetics, review, genomic imprinting, obesity, gene, disease, epigenesis, humans, quantitative trait, later life, risk, evolution, animals, development, environmental
145-154
Gluckman, P.D.
492295c0-ef71-4871-ad5a-771c98e1059a
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Beedle, A.S.
214bd9e6-598a-4761-b885-0466521ac623
2007
Gluckman, P.D.
492295c0-ef71-4871-ad5a-771c98e1059a
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Beedle, A.S.
214bd9e6-598a-4761-b885-0466521ac623
Gluckman, P.D., Hanson, M.A. and Beedle, A.S.
(2007)
Non-genomic transgenerational inheritance of disease risk.
BioEssays, 29 (2), .
(doi:10.1002/bies.20522).
Abstract
That there is a heritable or familial component of susceptibility to chronic non-communicable diseases such as type 2 diabetes, obesity and cardiovascular disease is well established, but there is increasing evidence that some elements of such heritability are transmitted non-genomically and that the processes whereby environmental influences act during early development to shape disease risk in later life can have effects beyond a single generation. Such heritability may operate through epigenetic mechanisms involving regulation of either imprinted or non-imprinted genes but also through broader mechanisms related to parental physiology or behaviour. We review evidence and potential mechanisms for non-genomic transgenerational inheritance of 'lifestyle' disease and propose that the 'developmental origins of disease' phenomenon is a maladaptive consequence of an ancestral mechanism of developmental plasticity that may have had adaptive value in the evolution of generalist species such as Homo sapiens
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Published date: 2007
Keywords:
cardiovascular-disease, origins, epigenetic, cardiovascular, heritable, prenatal exposure delayed effects, diabetes, growth, pregnancy, research, etiology, developmental plasticity, genetic, physiology, female, cardiovascular disease, genetics, review, genomic imprinting, obesity, gene, disease, epigenesis, humans, quantitative trait, later life, risk, evolution, animals, development, environmental
Identifiers
Local EPrints ID: 61160
URI: http://eprints.soton.ac.uk/id/eprint/61160
ISSN: 0265-9247
PURE UUID: 39d4fabc-d0e1-401b-896b-2637772bd4f6
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Date deposited: 04 Sep 2008
Last modified: 16 Mar 2024 03:17
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Author:
P.D. Gluckman
Author:
A.S. Beedle
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