Metabolic plasticity during mammalian development is directionally dependent on early nutritional status
Metabolic plasticity during mammalian development is directionally dependent on early nutritional status
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for most mammalian traits. The metabolic phenotype of adult rats, including the propensity to obesity, hyperinsulinemia, and hyperphagia, shows plasticity in response to prenatal nutrition and to neonatal administration of the adipokine leptin. Here, we report that the effects of neonatal leptin on hepatic gene expression and epigenetic status in adulthood are directionally dependent on the animal's nutritional status in utero. These results demonstrate that, during mammalian development, the direction of the response to one cue can be determined by previous exposure to another, suggesting the potential for a discontinuous distribution of environmentally induced phenotypes, analogous to the phenomenon of polyphenism
developmental plasticity, epigenetics, gene expression, leptin, obesity
12796-12800
Gluckman, Peter D.
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Lillycrop, Karen A.
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Vickers, Mark H.
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Pleasants, Anthony B.
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Phillips, Emma S.
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Beedle, Alan S.
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Burdge, Graham C.
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Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
July 2007
Gluckman, Peter D.
ef2e8b92-0b76-4a12-bd7c-01b0674f94d3
Lillycrop, Karen A.
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Vickers, Mark H.
6e05d089-9742-44f5-b4e1-3a505027d10c
Pleasants, Anthony B.
425875ca-16c7-4ad7-bf18-b6866f2c7237
Phillips, Emma S.
66ddd4cb-19a2-4d08-889b-12f418e6878b
Beedle, Alan S.
eab82133-3184-4952-9a1b-b93251840ad9
Burdge, Graham C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., Burdge, Graham C. and Hanson, Mark A.
(2007)
Metabolic plasticity during mammalian development is directionally dependent on early nutritional status.
Proceedings of the National Academy of Sciences of the United States of America, 104 (31), .
(doi:10.1073/pnas.0705667104).
Abstract
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for most mammalian traits. The metabolic phenotype of adult rats, including the propensity to obesity, hyperinsulinemia, and hyperphagia, shows plasticity in response to prenatal nutrition and to neonatal administration of the adipokine leptin. Here, we report that the effects of neonatal leptin on hepatic gene expression and epigenetic status in adulthood are directionally dependent on the animal's nutritional status in utero. These results demonstrate that, during mammalian development, the direction of the response to one cue can be determined by previous exposure to another, suggesting the potential for a discontinuous distribution of environmentally induced phenotypes, analogous to the phenomenon of polyphenism
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Published date: July 2007
Keywords:
developmental plasticity, epigenetics, gene expression, leptin, obesity
Organisations:
Dev Origins of Health & Disease
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Local EPrints ID: 61161
URI: http://eprints.soton.ac.uk/id/eprint/61161
ISSN: 0027-8424
PURE UUID: 42343fec-0bd4-459a-9a62-e1ae256fdb47
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Date deposited: 20 Mar 2009
Last modified: 16 Mar 2024 03:17
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Author:
Peter D. Gluckman
Author:
Mark H. Vickers
Author:
Anthony B. Pleasants
Author:
Emma S. Phillips
Author:
Alan S. Beedle
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