Effect of in utero and early-life conditions on adult health and disease
Effect of in utero and early-life conditions on adult health and disease
A long latency period between an environmental trigger and the onset of subsequent disease is widely recognized in the etiology of certain cancers, yet this phenomenon is not generally considered in the etiology of other conditions such as cardiovascular disease, metabolic disease, or osteoporosis. However, many lines of evidence, including epidemiologic data and data from extensive clinical and experimental studies, indicate that early life events play a powerful role in influencing later susceptibility to certain chronic diseases.
development, genetic, early-life, growth, prenatal nutrition physiology, infant, birth weight, nutrition physiology, research, adult, etiology, disease, epigenesis, review, adaptation, pregnancy, male, growth & development, humans, in-utero, gene expression regulation, female, newborn, biological, health, fetal development
61-73
Gluckman, Peter D.
ef2e8b92-0b76-4a12-bd7c-01b0674f94d3
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Thornburg, Kent L.
49e1e87d-82d6-41f3-894e-ece7a5a19651
2008
Gluckman, Peter D.
ef2e8b92-0b76-4a12-bd7c-01b0674f94d3
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Thornburg, Kent L.
49e1e87d-82d6-41f3-894e-ece7a5a19651
Gluckman, Peter D., Hanson, Mark A., Cooper, Cyrus and Thornburg, Kent L.
(2008)
Effect of in utero and early-life conditions on adult health and disease.
New England Journal of Medicine, 359 (1), .
Abstract
A long latency period between an environmental trigger and the onset of subsequent disease is widely recognized in the etiology of certain cancers, yet this phenomenon is not generally considered in the etiology of other conditions such as cardiovascular disease, metabolic disease, or osteoporosis. However, many lines of evidence, including epidemiologic data and data from extensive clinical and experimental studies, indicate that early life events play a powerful role in influencing later susceptibility to certain chronic diseases.
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Published date: 2008
Keywords:
development, genetic, early-life, growth, prenatal nutrition physiology, infant, birth weight, nutrition physiology, research, adult, etiology, disease, epigenesis, review, adaptation, pregnancy, male, growth & development, humans, in-utero, gene expression regulation, female, newborn, biological, health, fetal development
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Local EPrints ID: 61164
URI: http://eprints.soton.ac.uk/id/eprint/61164
PURE UUID: 36c5d542-dc60-4670-b650-a7a702fb7761
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Date deposited: 09 Sep 2008
Last modified: 18 Mar 2024 02:52
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Author:
Peter D. Gluckman
Author:
Kent L. Thornburg
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