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Early mortality from the time of diagnosis of Type 2 diabetes: a 5-year prospective cohort study with a local age- and sex-matched comparison cohort

Early mortality from the time of diagnosis of Type 2 diabetes: a 5-year prospective cohort study with a local age- and sex-matched comparison cohort
Early mortality from the time of diagnosis of Type 2 diabetes: a 5-year prospective cohort study with a local age- and sex-matched comparison cohort
AIMS: To study patterns and predictors of early mortality in individuals with a new diagnosis of Type 2 diabetes, compared with a local age- and sex-matched comparison cohort. METHODS: A total of 736 individuals diagnosed with Type 2 diabetes between 1 May 1996 and 30 June 1998 and non-diabetic age- and sex-matched control subjects were studied. Follow-up was 5.25 years. Age- and gender-specific all-cause mortality odds ratios were calculated for the diabetic cohort compared with the non-diabetic comparator group. Mortality odds ratios were ascertained using conditional logistic regression. RESULTS: There were 147 deaths in the diabetic cohort [cardiovascular (42.2%), cancer (21.1%)]. Compared with the non-diabetic cohort, mortality odds more than doubled [odds ratio (OR) 2.47; 95% confidence interval (CI) 1.74, 3.49]. These increased odds were present in all age bands (including those aged > 75 years at diagnosis) for both cardiovascular and non-cardiovascular causes. In women, a new diagnosis of Type 2 diabetes was associated with a sevenfold increase in mortality odds in those aged 60-74 years (OR 7.00; 95% CI 2.09, 23.47). CONCLUSIONS: Type 2 diabetes is associated with a 2.5-fold increase in the odds of mortality in both men and women over the first 5 years from diagnosis. Our data strongly support the contention that the mortality risk associated with Type 2 diabetes essentially exists from, or may even predate, the time of diagnosis.
cancer mortality, cardiovascular mortality, mortality, new diagnosis, type 2 diabetes
0742-3071
1164-1167
Guzder, R.N.
734c858d-5c8d-40f8-800b-bec95061cfec
Gatling, W.
20844dbd-6b21-42ea-8348-28b462584688
Mullee, M.A.
fd3f91c3-5e95-4f56-8d73-260824eeb362
Byrne, C.D.
1370b997-cead-4229-83a7-53301ed2a43c
Guzder, R.N.
734c858d-5c8d-40f8-800b-bec95061cfec
Gatling, W.
20844dbd-6b21-42ea-8348-28b462584688
Mullee, M.A.
fd3f91c3-5e95-4f56-8d73-260824eeb362
Byrne, C.D.
1370b997-cead-4229-83a7-53301ed2a43c

Guzder, R.N., Gatling, W., Mullee, M.A. and Byrne, C.D. (2007) Early mortality from the time of diagnosis of Type 2 diabetes: a 5-year prospective cohort study with a local age- and sex-matched comparison cohort. Diabetic Medicine, 24 (10), 1164-1167. (doi:10.1111/j.1464-5491.2007.02223.x).

Record type: Article

Abstract

AIMS: To study patterns and predictors of early mortality in individuals with a new diagnosis of Type 2 diabetes, compared with a local age- and sex-matched comparison cohort. METHODS: A total of 736 individuals diagnosed with Type 2 diabetes between 1 May 1996 and 30 June 1998 and non-diabetic age- and sex-matched control subjects were studied. Follow-up was 5.25 years. Age- and gender-specific all-cause mortality odds ratios were calculated for the diabetic cohort compared with the non-diabetic comparator group. Mortality odds ratios were ascertained using conditional logistic regression. RESULTS: There were 147 deaths in the diabetic cohort [cardiovascular (42.2%), cancer (21.1%)]. Compared with the non-diabetic cohort, mortality odds more than doubled [odds ratio (OR) 2.47; 95% confidence interval (CI) 1.74, 3.49]. These increased odds were present in all age bands (including those aged > 75 years at diagnosis) for both cardiovascular and non-cardiovascular causes. In women, a new diagnosis of Type 2 diabetes was associated with a sevenfold increase in mortality odds in those aged 60-74 years (OR 7.00; 95% CI 2.09, 23.47). CONCLUSIONS: Type 2 diabetes is associated with a 2.5-fold increase in the odds of mortality in both men and women over the first 5 years from diagnosis. Our data strongly support the contention that the mortality risk associated with Type 2 diabetes essentially exists from, or may even predate, the time of diagnosis.

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More information

Published date: October 2007
Keywords: cancer mortality, cardiovascular mortality, mortality, new diagnosis, type 2 diabetes

Identifiers

Local EPrints ID: 61189
URI: http://eprints.soton.ac.uk/id/eprint/61189
ISSN: 0742-3071
PURE UUID: 5f638169-bc69-46d6-8c8b-a6b58d938cf9
ORCID for C.D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753

Catalogue record

Date deposited: 01 Oct 2008
Last modified: 09 Jan 2022 03:00

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Contributors

Author: R.N. Guzder
Author: W. Gatling
Author: M.A. Mullee
Author: C.D. Byrne ORCID iD

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