The University of Southampton
University of Southampton Institutional Repository

A novel fifteen minute test for assessment of individual time-dependent clotting responses to aspirin and clopidogrel using modified thrombelastography

Record type: Article

BACKGROUND: A rapid, reliable, point of care test reflecting patient specific responses to antiplatelet therapy would be of great clinical value in percutaneous coronary intervention (PCI). The aim of this study was to establish whether modified thrombelastography (TEG) can be employed as a 15 minute test of individual patient responses to aspirin and clopidogrel using a novel parameter, percentage clotting inhibition (%CIn). METHODS AND RESULTS: Thirty healthy volunteers and 10 patients undergoing elective PCI were recruited into four groups: 10 volunteers received a single 300 mg dose of aspirin [A1]: 10 volunteers received aspirin 75 mg daily for 7 days [A2]: 10 volunteers received a 600 mg dose of clopidogrel [C1]: 10 patients received a 600 mg loading dose of clopidogrel prior to elective PCI [C2]. In all cases the area under the clotting response curve was measured at 15 minutes (AUC15) and used to calculate a novel parameter, percentage clotting inhibition (%CIn). Large differences were demonstrated in both aspirin and clopidogrel groups in response to therapy as assessed by both the area under the curve at 15 minutes and %CIn. Furthermore, the technique demonstrated important heterogeneity of time-dependent responses between individuals. CONCLUSION: Modified TEG, employing AUC15 and %CIn, is a promising tool for assessing responses to aspirin and clopidogrel. Further data are now required to assess the potential of this test to optimise individual therapy in PCI patients in order to detect and treat those patients with relative hypo-responsiveness to anti-platelet drugs.

Full text not available from this repository.

Citation

Hobson, Alex R., Petley, Graham W., Dawkins, Keith D. and Curzen, Nick (2007) A novel fifteen minute test for assessment of individual time-dependent clotting responses to aspirin and clopidogrel using modified thrombelastography Platelets, 18, (7), pp. 497-505. (doi:10.1080/09537100701329162).

More information

Published date: November 2007
Keywords: platelet, aspirin, clopidogrel, thrombelastography

Identifiers

Local EPrints ID: 61218
URI: http://eprints.soton.ac.uk/id/eprint/61218
ISSN: 0953-7104
PURE UUID: a1b39018-d687-4a76-a479-4fe9d4c669c9
ORCID for Graham W. Petley: ORCID iD orcid.org/0000-0002-3295-0444

Catalogue record

Date deposited: 03 Oct 2008
Last modified: 17 Jul 2017 14:22

Export record

Altmetrics

Contributors

Author: Alex R. Hobson
Author: Keith D. Dawkins
Author: Nick Curzen

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×