The University of Southampton
University of Southampton Institutional Repository

Birth weight and cardiac structure in children

Record type: Article

OBJECTIVE: Epidemiologic studies have shown associations between impaired fetal growth and risk for coronary heart disease in adults. The underlying mechanisms are unknown. We investigated whether restricted intrauterine growth affects cardiac structure. METHODS: We performed echocardiography on 216 9-year-old children who were measured previously at birth. The diameter of the coronary left and right main branches was derived from the widest dimension; total coronary artery diameter was calculated by adding the diameters of the left and right coronary arteries. Aortic root diameter, left atrial diameter, left ventricular diameter, left ventricular outflow tract diameter, and left ventricular mass were measured. RESULTS: On average, children who had weighed less at birth had a smaller total coronary artery diameter, aortic root diameter, and left ventricular outflow tract diameter after adjustment for gender, gestational age, current height and weight, and maternal height and prepregnant weight. For each SD increase in birth weight, total coronary diameter rose by 0.10 mm, log aortic root diameter rose by 1.5%, and log left ventricular outflow tract diameter rose by 1.6%. CONCLUSION: Impaired fetal growth may have long-term effects on cardiac structure. This may help to explain why adults whose birth weight was low are at greater risk for coronary heart disease.

Full text not available from this repository.

Citation

Jiang, Benyu, Godfrey, Keith M., Martyn, Christopher N. and Gale, Catharine R. (2006) Birth weight and cardiac structure in children Pediatrics, 117, (2), e257-e261. (doi:10.1542/peds.2005-1325).

More information

Published date: February 2006
Keywords: adult, disease, risk, weight, anatomy & histology, aorta, fetal, intrauterine growth, heart, left ventricular mass, mass, birth, gestational age, gender, research support, fetal-growth, coronary vessels, infant, female, coronary heart disease, birth-weight, growth, male, methods, echocardiography, birth weight, child, humans, newborn, coronary-heart-disease, maternal, cardiovascular disease, height

Identifiers

Local EPrints ID: 61251
URI: http://eprints.soton.ac.uk/id/eprint/61251
ISSN: 0031-4005
PURE UUID: ee48e069-3e59-46ea-9b4f-f45184c8a7ce
ORCID for Keith M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 01 Apr 2009
Last modified: 17 Jul 2017 14:22

Export record

Altmetrics

Contributors

Author: Benyu Jiang
Author: Christopher N. Martyn

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×