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Birth weight and cardiac structure in children

Jiang, Benyu, Godfrey, Keith M., Martyn, Christopher N. and Gale, Catharine R. (2006) Birth weight and cardiac structure in children Pediatrics, 117, (2), e257-e261.

Record type: Article


OBJECTIVE: Epidemiologic studies have shown associations between impaired fetal growth and risk for coronary heart disease in adults. The underlying mechanisms are unknown. We investigated whether restricted intrauterine growth affects cardiac structure. METHODS: We performed echocardiography on 216 9-year-old children who were measured previously at birth. The diameter of the coronary left and right main branches was derived from the widest dimension; total coronary artery diameter was calculated by adding the diameters of the left and right coronary arteries. Aortic root diameter, left atrial diameter, left ventricular diameter, left ventricular outflow tract diameter, and left ventricular mass were measured. RESULTS: On average, children who had weighed less at birth had a smaller total coronary artery diameter, aortic root diameter, and left ventricular outflow tract diameter after adjustment for gender, gestational age, current height and weight, and maternal height and prepregnant weight. For each SD increase in birth weight, total coronary diameter rose by 0.10 mm, log aortic root diameter rose by 1.5%, and log left ventricular outflow tract diameter rose by 1.6%. CONCLUSION: Impaired fetal growth may have long-term effects on cardiac structure. This may help to explain why adults whose birth weight was low are at greater risk for coronary heart disease.

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Published date: February 2006
Keywords: adult, disease, risk, weight, anatomy & histology, aorta, fetal, intrauterine growth, heart, left ventricular mass, mass, birth, gestational age, gender, research support, fetal-growth, coronary vessels, infant, female, coronary heart disease, birth-weight, growth, male, methods, echocardiography, birth weight, child, humans, newborn, coronary-heart-disease, maternal, cardiovascular disease, height


Local EPrints ID: 61251
ISSN: 0031-4005
PURE UUID: ee48e069-3e59-46ea-9b4f-f45184c8a7ce
ORCID for Keith M. Godfrey: ORCID iD

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Date deposited: 01 Apr 2009
Last modified: 29 Aug 2017 06:43

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Author: Benyu Jiang
Author: Christopher N. Martyn

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